Effects of Elaeagnus angustifolia L. powder supplementation on serum total antioxidant capacity and malondialdehyde levels in females with knee osteoarthritis
چکیده
Aim: The present study aimed to determine the effects of Elaeagnus angustifolia L. supplement on serum antioxidant status in females with knee osteoarthritis. Methods: In this 8-week randomized clinical trial, 90 females with knee osteoarthritis were randomly assigned to one of three groups medulla powder (15 g medulla powder), whole fruit powder (15 g whole fruit powder) or placebo. Information on dietary intake was collected using 24-h recall method for 3 days (one weekend day included). The serum levels of total antioxidant capacity (TAC) and malondialdehyde (MDA) were measured using the Randox (R) assay and the fluorometry method respectively. Paired sample t-test, ANOVA and ANCOVA were used for statistical analysis. Results: The mean serum TAC level in the medulla, whole fruit and placebo groups increased from 1.12 +/- 0.34 to 1.28 +/- 0.27, 1.30 +/- 0.28 to 1.50 +/- 0.28 and 1.18 +/- 0.19 to 1.30 +/- 0.22 mmol/L respectively. In terms of the TAC level, the significant increase was only observed in the whole fruit group (P=0.001). The mean serum MDA level in the medulla, whole fruit and placebo groups decreased from 3.80 +/- 0.33 to 3.30 +/- 0.41, 3.25 +/- 0.51 to 2.45 +/- 0.43 and 3.38 +/- 0.63 to 2.56 +/- 0.41, respectively. A statistically significant reduction was observed only in the whole fruit group (P=0.009). Discussion: Based on the results, E. angustifolia L. in the form of whole fruit had beneficial effects on serum TAC and MDA levels in females with knee OA. This may show a possible disease modifying effect of E. angusnfolia L. in knee osteoarthritis. (C) 2015 Elsevier GmbH. All rights reserved.