Solubilization of celecoxib, lamotrigine and phenytoin using ethanol and a nonionic surfactant

Abstract

Using micellar medium as a solubilization technique is an influential approach for solubilization of drugs with high hydrophobicity. It may be combined with cosolvency to provide more solubility. This work reports the effects of Tween 80 as a nonionic surfactant and ethanol as a commonly used cosolvent on the solubilities of celecoxib, phenytoin and lamotrigine at 298.2 K. As experimental results approved the effect of Tween 80 on the solubility of celecoxib is more than the others. The experimental data points were fitted to the Jouyban-Acree, general single and modified Wilson models and then back-calculated solubilities were calculated where the mean percentage deviations were 9.7%, 133% and 14.0%, respectively. (C) 2017 Elsevier B.V. All rights reserved.