Solubility prediction of deferiprone in N-methyl-2-pyrrolidone plus ethanol mixtures at various temperatures using a minimum number of experimental data

Abstract

Experimental solubility of deferiprone (DFP) in N-methyl-2-pyrrolidone (NMP) + ethanol (EtOH) mixtures at 293.2, 298.2, 303.2 and 308.2K was determined and mathematically represented using various models. The trained versions of the van't Hoff equation, its combined version with log-linear model, Jouyban-Acree model and a combination of van't Hoff + Jouyban-Acree model were reported to simulate DFP solubility in the binary mixture compositions at various temperatures. The mean percentage deviation (MPD) was used as an accuracy criterion. The obtained overall MPDs for back-calculated and predicted solubility of DFP in NMP + EtOH mixtures varied from 1.1% to 3.2% and 2.6% to 6.6%, respectively. Some of apparent thermodynamic quantities for the dissolution processes of DFP are also reported.