• English
    • Persian
    • English
    • Persian
  • Persian 
    • English
    • Persian
    • English
    • Persian
  • ورود
مشاهده آیتم 
  •   صفحه اصلی مخزن دانش
  • TBZMED Published Academics Works
  • Published Articles
  • مشاهده آیتم
  •   صفحه اصلی مخزن دانش
  • TBZMED Published Academics Works
  • Published Articles
  • مشاهده آیتم
JavaScript is disabled for your browser. Some features of this site may not work without it.

Nigella sativa Pretreatment in Guinea Pigs Exposed to Cigarette Smoke Modulates In Vitro Tracheal Responsiveness.

Thumbnail
تاریخ
2014
نویسنده
Keyhanmanesh, R
Nazemiyeh, H
Mazouchian, H
Bagheri Asl, MM
Karimi Shoar, M
Alipour, MR
Boskabady, MH
Metadata
نمایش پرونده کامل آیتم
چکیده
In previous studies, the bronchodilator and antitussive effects of Nigella sativa have been demonstrated on guinea pigs.In the present study, the effect of the hydroethanolic extract of N. sativa on tracheal responsiveness in guinea pigs exposed to cigarette smoke was examined.Three groups of guinea pig models of COPD were given drinking water alone (COPD group), drinking water containing vitamin C (COPD + VC group), and N. sativa (COPD + NS group). Tracheal responses to methacholine were measured as effective concentration causing 50% of maximum response (EC50 M) in control animals (group C) and three groups of guinea pigs with COPD (n = 7, for all groups). Tracheal responses to 0.1% ovalbumin in comparison to contraction obtained by 10 آµM methacholine were also examined.The tracheal responsiveness to both methacholine and ovalbumin in guinea pigs with COPD were significantly higher than those of controls (P < 0.001 for both cases). The tracheal responsiveness in the COPD + VC and the COPD + NS groups to both methacholine and ovalbumin were significantly decreased in comparison to the COPD group (P < 0.05 and P < 0.001, respectively).These results showed the preventive effect of hydroethanolic extract of N. sativa on tracheal responsiveness of guinea pig model of COPD, which was as effective as vitamin C.
URI
http://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/41424
Collections
  • Published Articles

مخزن دانش دانشگاه علوم پزشکی تبریز در نرم افزار دی اسپیس، کپی رایت 2018 ©  
تماس با ما | Send Feedback
Theme by 
Atmire NV
 

 

مرور

همه مخزنجامعه ها و مجموعه هابراساس تاریخ انتشارنویسنده هاعنوانهاموضوعاین مجموعهبراساس تاریخ انتشارنویسنده هاعنوانهاموضوع

حساب من

ورودثبت نام

مخزن دانش دانشگاه علوم پزشکی تبریز در نرم افزار دی اسپیس، کپی رایت 2018 ©  
تماس با ما | Send Feedback
Theme by 
Atmire NV