• English
    • Persian
    • English
    • Persian
  • English 
    • English
    • Persian
    • English
    • Persian
  • Login
View Item 
  •   KR-TBZMED Home
  • TBZMED Published Academics Works
  • Published Articles
  • View Item
  •   KR-TBZMED Home
  • TBZMED Published Academics Works
  • Published Articles
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Hydrogel nanoparticles and nanocomposites for nasal drug/vaccine delivery.

Thumbnail
Date
2016
Author
Salatin, S
Barar, J
Barzegar-Jalali, M
Adibkia, K
Milani, MA
Jelvehgari, M
Metadata
Show full item record
Abstract
Over the past few years, nasal drug delivery has attracted more and more attentions, and been recognized as the most promising alternative route for the systemic medication of drugs limited to intravenous administration. Many experiments in animal models have shown that nanoscale carriers have the ability to enhance the nasal delivery of peptide/protein drugs and vaccines compared to the conventional drug solution formulations. However, the rapid mucociliary clearance of the drug-loaded nanoparticles can cause a reduction in bioavailability percentage after intranasal administration. Thus, research efforts have considerably been directed towards the development of hydrogel nanosystems which have mucoadhesive properties in order to maximize the residence time, and hence increase the period of contact with the nasal mucosa and enhance the drug absorption. It is most certain that the high viscosity of hydrogel-based nanosystems can efficiently offer this mucoadhesive property. This update review discusses the possible benefits of using hydrogel polymer-based nanoparticles and hydrogel nanocomposites for drug/vaccine delivery through the intranasal administration.
URI
http://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/39855
Collections
  • Published Articles

Knowledge repository of Tabriz University of Medical Sciences using DSpace software copyright © 2018  HTMLMAP
Contact Us | Send Feedback
Theme by 
Atmire NV
 

 

Browse

All of KR-TBZMEDCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

LoginRegister

Knowledge repository of Tabriz University of Medical Sciences using DSpace software copyright © 2018  HTMLMAP
Contact Us | Send Feedback
Theme by 
Atmire NV