تهیه نانوپارتیکل های ناپروکسن با پلی لاکتیک گلیکولیک اسید و بررسی خصوصیات فیزیکوشیمیایی آنها

Abstract

PURPOSE Naproxen is a None Steroidal Anti Inflamatory Drug which can be used for treatment of inflammatory disorders like uveitis and Arthirit rheumatoid. For improving the physicochemical characteristics, in the current study the naproxen-PLGA nanoparticles were prepared and their physicochemical characteristics were assessed. METHODS. The nanoparticles of naproxen with PLGA were formulated using the modified quasi-emulsion solvent diffusion techniques. The physicochemical characteristics of nanoparticles were studied applying particle size analysis, differential scanning calorimetry, X-ray crystallography and Fourier transform infrared spectroscopy. Drug release profiles were examined by fitting the data to the kinetic models. The accuracy of the models was assessed employing mean percent error (E) and RSQ. RESULTS. All the prepared formulations using PLGA resulted in nano-range size particles (35223nm-59788nm). The nanoparticles of naproxen-PLGA displayed lower crystallinity with no chemical interactions between the drug and polymer molecules. The release profiles of naproxen from nanoparticles appeared to fit best with the linear probability model. CONCLUSIONS. According of these findings, formulation of the naproxen-PLGA nanoparticles was able to improve the physicochemical characteristics of the drug and possibly will increase the antiinflammatory effects of drug following its ocular or intra-joint administration. Keywords Nanoparticles, naproxen, Physicochemical characteristics, PLGA, Solvent evaporation.