تهیه نانوپارتیکل های ناپروکسن با پلی لاکتیک گلیکولیک اسید و بررسی خصوصیات فیزیکوشیمیایی آنها
چکیده
PURPOSE Naproxen is a None Steroidal Anti Inflamatory Drug which can be
used for treatment of inflammatory disorders like uveitis and Arthirit rheumatoid.
For improving the physicochemical characteristics, in the current study the
naproxen-PLGA nanoparticles were prepared and their physicochemical
characteristics were assessed. METHODS. The nanoparticles of naproxen with
PLGA were formulated using the modified quasi-emulsion solvent diffusion
techniques. The physicochemical characteristics of nanoparticles were studied
applying particle size analysis, differential scanning calorimetry, X-ray
crystallography and Fourier transform infrared spectroscopy. Drug release profiles
were examined by fitting the data to the kinetic models. The accuracy of the
models was assessed employing mean percent error (E) and RSQ. RESULTS.
All the prepared formulations using PLGA resulted in nano-range size particles
(35223nm-59788nm). The nanoparticles of naproxen-PLGA displayed lower
crystallinity with no chemical interactions between the drug and polymer
molecules. The release profiles of naproxen from nanoparticles appeared to fit
best with the linear probability model. CONCLUSIONS. According of these
findings, formulation of the naproxen-PLGA nanoparticles was able to improve
the physicochemical characteristics of the drug and possibly will increase the antiinflammatory
effects of drug following its ocular or intra-joint administration.
Keywords Nanoparticles, naproxen, Physicochemical characteristics, PLGA, Solvent evaporation.