A Comparison effect of aloevera gel and adcortyle ointment in treatment of oral lichen planus

Abstract

Oral lichen planus (OLP) is a relatively common chronic informmatory diseases of oral mucosa with a prevalence rate of 0/5% -2/2% etiology of the OLP is unknown. A variety of treatments have been proposed for OLP: tipical or systemic corticosteroids, cyclosporine, retinoids, azathioprine, tacrolimus, pimecrolimus, photochemotherapy and surgery. Patients with symptomatic OLP often require intensive therapy to reduce the signs and symptoms that can alter patient quality of life. On the other hand , there is some reports about anti-inflammatory properties of Aloe Vera (AV) gel with no side effect reported. The objective of this study was to evaluate the efficacy of the topical application of Aloe Vera (AV) in OLP compared with adcortyle. Materials and methods: In this study 20 patient were chosen and divided into two groups randomly to use either AV gel or Adcortyle. Duration of treatment was 2 weeks and patients were followed after each week and after first month too. In this case-control study we applied independent t-test to compare mean difference and we used SPSS.15 computer software (P<0/05). Results: AV gel in more effective that adcortyle in reduction of pain and size of lesions in OLP. Conclusion: using AV gel is an effective treatment for OLP and can improve the quality of life in patients with OLP.