Assesment of Serum histidine- rich glycoprotein with clinical manifestations and their correlation with disease activity in lupus and lupus nephritis

Abstract

Systemic lupus erythematosus is an autoimmune disease that can affect any organ in the body. The main mechanism in this disease is believed to be a disorder in the removal of apoptotic cells due to dysfunction of phagocytes. Histidine-rich glycoprotein (HRG) is a single polypeptide chain protein that has several mechanisms involved in regulating the body's immune response. Therefore, in this study, we aimed to investigate the relationship between HRG levels and disease activity in patients with lupus nephritis. Method: In this study, 26 patients with lupus nephritis and 34 lupus patients without symptoms of renal involvement, as well as 29 healthy individuals were included in the study as a control group. Demographic, clinical and laboratory information in patients were examined and finally compared between groups of patients. The SLEDAI criterion was used to assess disease activity. Results; There was a significant relationship between HRG level and disease severity based on SLEDAI among SLE patients. The association between patients without nephritis was stronger than that between all patients. HRG levels in SLE patients are also significantly lower than in healthy individuals. The only features of the patients that differed between the two groups of lupus patients without nephritis and with nephritis were the patients' hypertension and cellulose consumption, both of which were more common among patients with nephritis.