Solubility of atenolol, amiodarone HCl and lamotrigine in polyethylene glycol 200+water mixtures in the presence of beta-cyclodextrin

Abstract

Solubilities of three drugs, i.e. atenolol, amiodarone HCl and lamotrigine in binary mixtures of polyethylene glycol 200 + water in the presence of beta-cyclodextrin (beta-CD) along with the solubilities of atenolol and atniodarone HCl in this solvent tnixture in the absence of beta-CD using saturating shake flask method were studied. The generated solubility data was fitted to the Jouyban-Acree model and the solubility profile of each drug in the presence of beta-CD was compared with solubility data in the absence of beta-CD that the solubility data of lamotrigine taken from a previous paper.