School of Advanced Medical Sciences

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This faculty is the second largest faculty for Advanced Medical Science in IRAN in terms of variety of disciplines and courses as well as availability of advanced technologies. This faculty offers graduate courses in two disciplines for Master of Science and Ph.D programs. The Students enjoy educating in Medical Biotechnology, Medical Nanotechnology, Molecular Medical , Nuro Sciences, Medical Engineering, Tissue Engineering and Reproduce Medicine. We have an active gradual program with more than 120 students pursuing further education in diverse areas of Advanced Medical Sciences. We recognize the importance of inter-disciplinary research and advanced technologic developments which has had led to collaboration `with other research centers in the campus and other universities in Iran and all over the world. Through the web-site you will find the information on the faculty, staff and students, degree and program courses, research and basic and clinical interests as well as current events.

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Author: search.filters.author.Askari, Shivadokht

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    Preparation and Evaluation of effect Magnetic Nanoparticles Modified with Biodegradable Copolymer PCL-PEG containing Curcumin – Silibinin on Leptin Gene Experession in Lung Cancer
    (Tabriz University of Medical Sciences Faculty of Advanced Medical Science, 2015) Askari, Shivadokht; Akbarzadeh, Abolfazl; Medical nanotechnology; Rahmati, Mohammad; Zarghami, Nosratollah
    Lung cancer is the most lethal invasive disease in women and men .Leptin is a derivative of the adipocytes tissue has an important role in lung cancer. Curcumin (CUR) and silibinin (SIL) are herbal compounds which have many anticancer properties .CUR-SLN loaded MNPs PCLPEG improved inhibitory effect on leptin gene expersion. Purpose The purpose of this study was to investigate the efficiency of pure CURSLN and MNPs PCL-PEG on leptin gene expersion in A549 lung cancer cell line . Methods and Materials In the current study,the triblock copolimer PCL–PEG–PCL MNPs successfully synthesized by the method of ring-opening polymerization and encapsulated on PCL-PEG copolymer ,dual agents curcumin and silibinin . After A549 cell culturing ,MTT assay used to evaluated cytotoxic effects of free CUR-SLN and MNPs CUR-SLN and IC50 was calculated .Then A549 cells treaded with different concentrations of free CUR-SLN and CUR-SLN loaded on MNPs. Finally , leptin gene expersion level was compared by Real-time PCR. Result Synthesis of MNPs PCL-PEG and drug loading on nanoparticles was confirmed with using SEM, 1HNMR, FT-IR and VSM methods . Recent work has shown that CUR-SLN-loaded MNPs modified with PCL-PEGPCL triblock copolymers have potent time- and dose-dependent antigrowth effects in an A549 cell line. Real time PCR showed that CUR-SLN loaded on MNPs in compare with free CUR-SLN the target gene expression levels were reduced by half. 103 Conclusion Given the important role that leptin gene in lung cancer and magnetic nano-particle effective role in targeted drug delivery, nanoparticles containing curcumin and Silibinin as effective plant compounds to inhibit leptin gene expersion can be appropriate option.
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    Preparation and Evaluation of effect Magnetic Nanoparticles Modified with Biodegradable Copolymer PCL-PEG containing Curcumin – Silibinin on Leptin Gene Experession in Lung Cancer
    (Tabriz University of Medical Sciences Faculty of Advanced Medical Science, 2015) Askari, Shivadokht; Medical Biotechnology; Zarghami, Nosratollah; Rahmati, Mohammad
    Given the important role that leptin gene in lung cancer and magnetic nano-particle effective role in targeted drug delivery, nanoparticles containing curcumin and Silibinin as effective plant compounds to inhibit leptin gene expersion can be appropriate option.