School of Pharmacy

Permanent URI for this communityhttps://dspace.tbzmed.ac.ir/handle/123456789/5

The School of Pharmacy, as the second pharmacy faculty in Iran after Tehran pharmacy school in 1328 Hejri Shamsi , was located at Tabriz Imam Khomeyni square and Ayatollah Taleghani Street ,was established to provide the country needs to pharmacist. This major change occurs when there was no pharmacy school in Tabriz and pharmacy personnels learn it experimently and finally reach the stage of dispensering . Permission to establish a pharmacy was given after passing the test which requires the literacy and knowing Latin language and dispenesring. Tabriz pharmacy faculty is established after student advertising admission. At the first reception, the number of students did not pass, But college starts first training cources with 25 students. After 2-year curriculum of courses, the speciality pharmaceutical topics were teached. Toxicology and jalinoosi products were as specialized courses. Later by the dean Department , Dear doctor Ismaiil Anghajy , basic steps were taken for developing the faculty. School of Pharmacy began its own activities with medicine school and gained independence in 1345.following the dissolution of the pharmacy schools in whole country in September 1347, a new school of pharmaceutical and clinical laboratory sciences began its own activities.The pharmacy faculty was established with the aim of training pharmacy students and drug experts to manage pharmacy, Pharmaceutical industry,economy of country and training experts to work in clinical laboratory and searching in pharmacy and the laboratory. The Department of Laboratory science was transferred Medicine faculty in 1351. The Nutrition school within Tabriz Pharmacy Faculty began its academic activities with 39 students in 1353 and with the establishment of the health and nutrition school it was separated from pharmacy faculty in 1370. The new building for the School of Pharmacy started with an area of ​​17,000 square meters in 1386. Tabriz School of Pharmacy has more than 3000 pharmacy graduated is delivered to our country that many of them , have been efficient and effective rules in Pharmaceutical Science. currently Tabriz School of Pharmacy consists of 7 Department of Pharmaceutic, Pharmacology and Toxicology, Pharmacognosy, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Clinical Pharmacy and Food and Drug Control. Faculty Education departments and physical facilities with high knowledge of professors tries to through training programs, basic and applied researches and provide services , solve problems with use of a pharmacy modern knowledge and Significant contribution in scientific development of their own country. Training courses for PhD students starts in field of Pharmacognosy in Tabriz school of pharmacy . now 62 PhD students are studing in Tabriz Pharmacy faculty in the field of Pharmacognosy, Pharmaceutics, Pharmacology, Pharmaceutical Chemistry, Toxicology, Biotechnology, pharmaceutical and food and drug control. Tabriz Pharmacy school is located at the heart of the city where the science and art were born. preserved old town in the vicinity of modern development, its proximity to the Shahand mountain that always carrying snow and Uromiye lake and ... causes the city unforgettable for students who live and study in it.

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  • Item type: Item ,
    Preparation of hydrolyzed peptides from spirulina algae protein and their encapsulation in nanoliposome systems and their effectiveness study on skin aging process
    (Tabriz University of Medical Sciences, School of Pharmacy, 2024) Naderi, Sina; Barzegar jalali, Mohammad; Hamishehkar, Hamed
    Introduction: Spirulina platensis is a type of blue-green algae that contains large amounts of protein with therapeutic effects. Objective: The present study was conducted to investigate the effects of spirulina protein hydrolysis encapsulated with nanoliposomes in skin rejuvenation.Methods: First, proteins extracted from spirulina algae were hydrolyzed by pepsin, trypsin, etc. enzymes and loaded into nanoliposome systems. Toxicity studies using MTT method on cell line (HFF-2) showed that hydrolyzed peptides increased cell growth. For the in vivo study, 70 mice were divided into 4 groups, including mice treated with empty nanoliposomes, spirulina protein hydrolysis, nanoliposomes loaded with spirulina protein hydrolysis, and the commercial group, and 2 control groups. To create an aging model, mice were exposed to UV radiation for 30 minutes daily for 1 month, and D-galactose sugar was injected subcutaneously. The products were used for 2 months. Immunofluorescence staining was performed to investigate Elastin and COL1A and western blot was performed to investigate the expression of MMP-2, MMP-9 and JNK.Results: The results showed that the group of mice treated with skin aging showed fibroblast proliferation and higher expression for MMP2, MMP9, JNK, Elastin and COL1A compared to blanks and other groups. The nanoliposomes loaded with spirulina protein hydrolysis showed the size and zeta potential of 158 nm and -48 mV, respectively.Conclusion: In this study, we found out that Spirulina algae proteins that are hydrolyzed by different enzymes show different biological properties. Spirulina peptide hydrolysis increased the population of HFF2 cells. Based on the findings of the in vivo section, the encapsulation of spirulina algae peptide hydrolysis by NLP accelerated the skin rejuvenation process by increasing the expression of Elastin and COL1A, decreasing the expression of JNK. In conclusion, the developed algae-based nanostructured gel can be a potential candidate for application in skin rejuvenation after comprehensive studies.
  • Item type: Item ,
    Preparation of Flucytosine loaded liposomes and evaluation of the in vitro antifungal effect on Candida glabrata compared to the drug solution
    (Tabriz University of Medical Sciences, Faculty of Pharmacy, 2019) Esmailpour, Payam; Hallaj Nezhadi, Somayeh; Dilmaghani, Azita
    Introduction: Flucytosine has attained approval as an adjunct antifungal agent in the treatment of systemic Candida or Cryptococcus infections. Off-label, flucytosine is utilized in treating pediatric endocarditis caused by Aspergillus spp Flucytosine is an antimetabolite compound absorbed into fungal cells via cytosine permease. Within the fungal cell, flucytosine gets converted to 5-fluorouracil, which interferes with fungal RNA biosynthesis Aim: The main objective of this investigation was to encapsulate fluocytosine in the nanoliposomal formulation to study their antifungal activities in vitro against Candida glabrata yeast. Methods: Different liposomal formulations of 5-FC were prepared based on the modified freeze-drying of a monophase solution. The liposomes were characterized in terms of Size, Zeta potential, Polydispersity index, Tem and Encapsulation efficiency. Also, MICs of free and nanoliposomal 5-FC against Candida glabrata yeast were investigated by the standard broth macro-dilution method. Results: The size and zeta potential of the prepared liposomes were from 178.7 to 523.8 nm, and -65.55 to -31.35mV, respectively. Encapsulation efficiency was 41.31% in the best formulation. Also, TEM results showed that the liposomes were nano-sized and spherical in shape. Most importantly, Fungal eradication by liposomal 5-FC (MIC=0.058 µg/ml) was about 2-fold higher than free 5-FC (MIC = 0.11 μg / ml) for Candida glabrata. Conclusions: Nanoliposomal 5-FU prepared using the modified freeze-drying of a monophase solution method could increase the entrapment efficiency as well as the antifungal effect of the antibiotic compared to the drug solution
  • Item type: Item ,
    Preparation of Flucytosine loaded liposomes and evaluation of the in vitro antifungal effect on Candida glabrata compared to the drug solution
    (Tabriz University of Medical Sciences, Faculty of Pharmacy, 2019) Esmailpour, Payam; Hallaj Nezhadi, Somayeh; Azita, Dilmaghani
    Introduction: Flucytosine has attained approval as an adjunct antifungal agent in the treatment of systemic Candida or Cryptococcus infections. Off-label, flucytosine is utilized in treating pediatric endocarditis caused by Aspergillus spp Flucytosine is an antimetabolite compound absorbed into fungal cells via cytosine permease. Within the fungal cell, flucytosine gets converted to 5-fluorouracil, which interferes with fungal RNA biosynthesis Aim: The main objective of this investigation was to encapsulate fluocytosine in the nanoliposomal formulation to study their antifungal activities in vitro against Candida glabrata yeast. Methods: Different liposomal formulations of 5-FC were prepared based on the modified freeze-drying of a monophase solution. The liposomes were characterized in terms of Size, Zeta potential, Polydispersity index, Tem and Encapsulation efficiency. Also, MICs of free and nanoliposomal 5-FC against Candida glabrata yeast were investigated by the standard broth macro-dilution method. Results: The size and zeta potential of the prepared liposomes were from 178.7 to 523.8 nm, and -65.55 to -31.35mV, respectively. Encapsulation efficiency was 41.31% in the best formulation. Also, TEM results showed that the liposomes were nano-sized and spherical in shape. Most importantly, Fungal eradication by liposomal 5-FC (MIC=0.058 µg/ml) was about 2-fold higher than free 5-FC (MIC = 0.11 μg / ml) for Candida glabrata. Conclusions: Nanoliposomal 5-FU prepared using the modified freeze-drying of a monophase solution method could increase the entrapment efficiency as well as the antifungal effect of the antibiotic compared to the drug solution