School of Pharmacy

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The School of Pharmacy, as the second pharmacy faculty in Iran after Tehran pharmacy school in 1328 Hejri Shamsi , was located at Tabriz Imam Khomeyni square and Ayatollah Taleghani Street ,was established to provide the country needs to pharmacist. This major change occurs when there was no pharmacy school in Tabriz and pharmacy personnels learn it experimently and finally reach the stage of dispensering . Permission to establish a pharmacy was given after passing the test which requires the literacy and knowing Latin language and dispenesring. Tabriz pharmacy faculty is established after student advertising admission. At the first reception, the number of students did not pass, But college starts first training cources with 25 students. After 2-year curriculum of courses, the speciality pharmaceutical topics were teached. Toxicology and jalinoosi products were as specialized courses. Later by the dean Department , Dear doctor Ismaiil Anghajy , basic steps were taken for developing the faculty. School of Pharmacy began its own activities with medicine school and gained independence in 1345.following the dissolution of the pharmacy schools in whole country in September 1347, a new school of pharmaceutical and clinical laboratory sciences began its own activities.The pharmacy faculty was established with the aim of training pharmacy students and drug experts to manage pharmacy, Pharmaceutical industry,economy of country and training experts to work in clinical laboratory and searching in pharmacy and the laboratory. The Department of Laboratory science was transferred Medicine faculty in 1351. The Nutrition school within Tabriz Pharmacy Faculty began its academic activities with 39 students in 1353 and with the establishment of the health and nutrition school it was separated from pharmacy faculty in 1370. The new building for the School of Pharmacy started with an area of ​​17,000 square meters in 1386. Tabriz School of Pharmacy has more than 3000 pharmacy graduated is delivered to our country that many of them , have been efficient and effective rules in Pharmaceutical Science. currently Tabriz School of Pharmacy consists of 7 Department of Pharmaceutic, Pharmacology and Toxicology, Pharmacognosy, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Clinical Pharmacy and Food and Drug Control. Faculty Education departments and physical facilities with high knowledge of professors tries to through training programs, basic and applied researches and provide services , solve problems with use of a pharmacy modern knowledge and Significant contribution in scientific development of their own country. Training courses for PhD students starts in field of Pharmacognosy in Tabriz school of pharmacy . now 62 PhD students are studing in Tabriz Pharmacy faculty in the field of Pharmacognosy, Pharmaceutics, Pharmacology, Pharmaceutical Chemistry, Toxicology, Biotechnology, pharmaceutical and food and drug control. Tabriz Pharmacy school is located at the heart of the city where the science and art were born. preserved old town in the vicinity of modern development, its proximity to the Shahand mountain that always carrying snow and Uromiye lake and ... causes the city unforgettable for students who live and study in it.

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    Evaluation of the effect of pentoxifylline and natural honey on morphine dependence in mice
    (Tabriz University of Medical Sciences, School of Pharmacy, 2025) Rabiei, Erfan; Habibi Asl, Bohlool; Najafi, Moslem
    Introduction: In the process of forming dependence and tolerance to opioids, various mechanisms such as increased oxidative stress, increased activity of the glutaminergic system, etc. are observed. Pentoxifylline and natural honey are among the drugs with antioxidant properties. Aim: The purpose of this study was evaluation the effect of pentoxifylline and natural honey on morphine dependence in mice.Methods: 90 male mice in 9 groups of 10 in the weight range of 20-30 g were randomly selected and received the following medication regimens once a day for two weeks. 1-Saline (10ml/kg,ip) +Saline (10ml/kg,ip) 2-Saline (10ml/kg,ip) + Morphine (25mg/kg,ip) 3,4,5- pentoxifylline (20,40,80mg/kg,ip) + Morphine (25mg/kg,ip) 6,7,8-Natural Honey (100,200,400mg/kg,ip) + Morphine (25mg/kg,ip) 9- pentoxifylline (20mg/kg,ip) + Honey (100mg/kg,ip) + Morphine (25mg/kg,ip) On the fourteenth day, naloxone (4mg / kg, ip) was injected into animals two hours after morphine injection and withdrawal symptoms were measured within half an hour. Finally, to measure serum MDA and TAC levels in different groups, the animals were anesthetized and blood samples were taken from the heart.Results: The results showed that intraperitoneal injection of honey in 3 doses (100, 200 and 400 mg/kg) and pentoxifylline with a dose of (20, 40, 80 mg/kg) each alone causes a significant reduction in the symptoms of morphine dependence.Conclusion: The findings of our study showed that the chronic consumption of honey in a non-dose-dependent manner and pentoxifylline in a dose-dependent manner had a beneficial effect in reducing the symptoms of morphine withdrawal syndrome and this effect is probably related to the anti-inflammatory properties of flavonoids in Honey and the antioxidant effects of pentoxifylline.
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    Evaluation of the effect of dextromethorphan and bupropion in reversing morphine-induced tolerance in mice
    (Tabriz University of Medical Sciences, School of Pharmacy, 2025) Hemmaty Pour, Sina; Habibi Asl, Bohlool; Charkhpour, Mohammad; Parvizpur, Alireza
    Introduction: Changes in the function of glutamatergic, dopaminergic and adrenergic systems are among the changes that occur in chronic morphine use. Dextromethorphan is an antitussive and has inhibitory effects on NMDA receptors. Bupropion, as an antidepressant, inhibits the metabolism of dextromethorphan and increases its release into the CNS. Aim: The aim of the study was to evaluate the effect of dextromethorphan and bupropion in the treatment of morphine-induced tolerance in mice. Material & Method: several mices (11 groups, 10 in each, 20-30g) were randomly selected for the following regimens for 17 days: 1. Saline (10ml/kg, 1st-17th days, S.C.) + Saline (10ml/kg, 11th-17th days, S.C.) 2. Morphine (10mg/kg, 1st-17th days, S.C.) + Saline (10ml/kg, 11th-17th days, S.C.) 3, 4, 5. Morphine (10mg/kg, 1st-17th days, S.C.) + Dextromethorphan (15,30,60 mg/kg/12h, 11th-17th days, S.C.) 6, 7, 8. Morphine (10mg/kg, 1st-17th days, S.C.) + Bupropion (40,80,110 mg/kg/12h, 11th-17th days, S.C.) 9, 10, 11. Morphine (10mg/kg, 1st-17th days, S.C.) + Dextromethorphan (15,30,60 mg/kg/12h, 11th-17th days, S.C.) + Bupropion (110,80,40 mg/kg/12h, 11th-17th days, S.C.). once on day11 and once on day17, the hotplate test was performed by injecting a test-dose morphine (9mg/kg) to animals. Results: Injection of dextromethorphan (15mg/kg) and bupropion (80mg/kg and 110mg/kg) and co-injection of dextromethorphan (15mg/kg) and bupropion (110mg/kg) accelerated tolerance compared to S+M group. However, in the injection of bupropion (40mg/kg) and co-injection of dextromethorphan (60mg/kg) and bupropion (40mg/kg), we observed a delay in tolerance compared to S+M group. Significant changes were also observed in MDA and TAC levels in bupropion (mg/kg 40) and dextromethorphan (60mg/kg) and bupropion (40mg/kg) groups compared to S+M group. Conclusion: The co-injection of dextromethorphan (60mg/kg) and bupropion (40mg/kg) and use of bupropion (40mg/kg) seem to be suitable for delaying tolerance to morphine; further studies are needed to observe precise mechanisms.
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    The preventive effect of bee pollen methanolic extract on morphine-induced tolerance and dependence in male mice
    (Tabriz University of Medical Sciences, School of Pharmacy, 2025) Pourreza Soltan Ahmadi, Ferdous; Habibi Asl, Bohlol; Eteraf Oskouei, Tahereh
    Introduction: The treatment of chronic pain presents a considerable difficulty, particularly due to opioid dependence, which is marked by tolerance and withdrawal symptoms. The mechanisms involved in the development of morphine tolerance and dependence include increased expression of P-glycoproteins and NMDA receptors, as well as activation of the oxidative stress system. Bee pollen, with its antioxidant effects and anti-inflammatory appears to have beneficial effects in preventing morphine tolerance and dependence.Aim: To evaluate the effects of bee pollen on morphine-induced tolerance and dependence in male mice.Methods: Fifty male mice (20–30 g) were randomly divided into 5 groups and subjected to the following regimens for 10 days: Saline control group, morphine control group, and three groups receiving bee pollen (12/5, 25, 50 mg/kg). On the eleventh day, following the acquisition of base latency time from the animals, morphine (9 mg/kg, ip) was administered, and the hot plate test was conducted over one hour. One hour after the hot plate test, naloxone (4 mg/kg, ip) was injected, and withdrawal symptoms (jumping and standing) were measured over 30 minutes. Blood samples were then collected, and the serum was separated to determine for the determination of serum levels of MDA and TAC. Results: Pretreatment by bee pollen, before morphine administration, decreased the development of tolerance to the antinociceptive action of morphine and also reduced naloxone-precipitated withdrawal jumps and standing on feet.Conclusion: Bee pollen (12/5, 25, 50 mg/kg, ip) reduces prevents morphine dependence and tolerance in animals, most likely due to its beneficial mechanisms through the inhibition of the oxidative stress system.
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    Evaluation of the effect of chronic administration of pirfenidone on the tolerance to the analgesic effects of morphine in male mice
    (Tabriz University of Medical Sciences, School of Pharmacy, 2025) Rostamzadeh, Shiva; Charkhpour, Mohammad; Parvizpour, Alireza
    Introduction: The chronic use of opioids causes dependence and tolerance towards them, and various mechanisms such as oxidative stress and increased production of inflammatory factors are involved in this process; The antioxidant and anti-inflammatory effects of pirfenidone have been proven. Aim: The current study aimed to investigate the effect of chronic administration of pirfenidone on the tolerance to the analgesic effects of morphine in mice.Methods: The experiment was conducted in 6 groups of 8 mice, in first group, 8 mice were given two injections every day at interval of half an hour and each time 10 (ml/kg, i.p.) of normal saline, in second group, 10 (ml/kg) every day. kg, i.p) morphine and half an hour before that 10 (ml/kg, i.p) normal saline, in third group morphine (mg/kg, i.p 10) and half an hour before that 1 ml/kg containing pirfenidone DMSO (10%) and in other three groups, we injected three different doses of pirfenidone (25/50/100 mg/kg, i.p.) one hour before morphine. In all groups, we performed a hot plate test every other day for half an hour after the injections. Finally, blood was taken from all groups and TAC, MDA, TNF-a, IL-1, and IL-6 factors were analyzed. Results: In the group receiving vehicle and morphine on day 5 and in the groups receiving doses of 25, 50 and 100 mg/kg pirfenidone along with morphine on days 11, 11 and 3, respectively, tolerance was established, but only the dose of 25 mg/kg pirfenidone was significantly (P<0.05) delayed tolerance to morphine. Also, the level of inflammatory factor IL-6 showed a significant difference (P<0.001) only in the group receiving the pirfenidone (25 mg/kg) compared to the morphine group. Conclusion: Probably, pirfenidone (25 mg/kg) delayed the onset of tolerance to morphine due to its anti-inflammatory effects. We need more studies to understand it better.
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    Evaluation of the effects of Carvacrol on Morphine induced tolerance and dependence in male mice
    (Tabriz University of Medical Sciences, School of Pharmacy, 2024) Kenarangi, Farzaneh; Habibi Asl, Bohlol; Khalili Fard, Javad
    Introduction: The mechanisms involved in the development of morphine tolerance and dependence include increased expression of P-glycoproteins and NMDA receptors, as well as activation of the oxidative stress system. Carvacrol, with its antioxidant effects, inhibition of P-gp gene expression, and NMDA receptor inhibition, appears to have beneficial effects in preventing morphine tolerance and dependence.Aim: To evaluate the effects of carvacrol on morphine-induced tolerance and dependence in male mice.Methods: Fifty male Swiss mice (weighing 20–30 grams, n=5) were randomly divided and subjected to the following regimens for 10 days: saline control group, morphine control group, and three groups receiving carvacrol (10, 20, 40 mg/kg). On the eleventh day, following the acquisition of base latency time from the animals, morphine (9 mg/kg, ip) was administered, and the hot plate test was conducted over one hour. One hour after the hot plate test, naloxone (4 mg/kg, ip) was injected, and withdrawal symptoms (jumping and rearing) were measured over 30 minutes. Blood samples were then collected, and the serum was separated for the determination of serum levels of MDA and TAC.Results: Administration of different doses of carvacrol (10, 20, 40 mg/kg, ip) did not cause significant changes in morphine tolerance reduction. However, administration of carvacrol (20, 40 mg/kg, ip) resulted in a significant decrease (**P<0.01) in morphine-induced dependence. Carvacrol (20, 40 mg/kg, ip) significantly decreased (***p<0.001) the serum MDA level, and carvacrol (40 mg/kg, ip) significantly increased (**p<0.01) the serum TAC level compared to the morphine control group. Conclusion: Carvacrol (20, 40 mg/kg, ip) prevents morphine dependence in animals, likely due to its beneficial mechanisms through the inhibition of the oxidative stress system.
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    Evaluation of the effects of Thymus vulgaris essential oil in preventing morphine-induced tolerance and dependence in male mice
    (Tabriz University of Medical Sciences, School of Pharmacy, 2024) Safari, Azin; Habibi Asl, Bohlol; Khalili Fard, Javad
    Introduction: Previous research has demonstrated the roles of the glutamatergic system and oxidative stress in the development of morphine tolerance and dependence. Thymus vulgaris essential oil, due to its antioxidant properties and inhibitory effects on NMDA receptors, may effectively prevent morphine-induced tolerance and dependence.Aim: The aim of this study was evaluating the effects of intraperitoneal administration of Thymus vulgaris essential oil in preventing morphine-induced tolerance and dependence in male mice.Methods: Fifty male mice (20-30 grams) were randomly assigned to five groups of ten: a saline control group, a morphine control group, and three groups receiving Thymus vulgaris essential oil at doses of (25, 50, 100 mg/kg, i.p.). Treatments were administered daily for ten consecutive days. The essential oil was injected 30 minutes prior to the daily morphine injection. On day eleven, baseline measurements were taken, followed by the administration of morphine (9 mg/kg, i.p.) and the hot plate test was conducted within one hour. One hour after the hot plate test, naloxone (5 mg/kg, i.p.) was injected, and withdrawal symptoms were recorded for 30 minutes. The animals were then anesthetized, and blood samples were collected from the heart to measure serum levels of malondialdehyde (MDA) and total antioxidant capacity (TAC).Results: Administration of Thymus vulgaris essential oil at all doses (25, 50, 100 mg/kg, i.p.) significantly prevented morphine-induced tolerance and dependence (***P<0.001). The highest dose (100 mg/kg, i.p.) significantly decreased serum MDA levels (***P<0.001) and increased serum TAC levels (*P<0.05).Conclusion: The results suggest that Thymus vulgaris essential oil prevents morphine-induced tolerance and dependence, partially through its inhibitory effects on oxidative stress. Further studies are recommended to evaluate its potential in managing morphine-induced tolerance and dependence.
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    Investigating the effects of pantoprazole on morphine-induced tolerance in mice
    (Tabriz University of Medical Sciences, School of Pharmacy, 1403) Hemmati, Faezeh; Habibi Asl, Bohlol; Eteraf Oskouei, Tahereh
    Introduction: Chronic use of opioid leads to development of tolerance to their analgesic effects. The reasons for this tolerance are increase in inflammatory factors and gene expression of P-glycoprotein (P-gp). In some studies, it has been reported that pantoprazole inhibits P-gp gene expression and/or P-gp protein itself.Aim: The objective of this study was to evaluate the effects of pantoprazole on morphine-induced tolerance in male albino Swiss mice. Materials and methods: 80 male mice (20-30g) were randomly divided into two treatment and prevention main groups. Each main group was further divided into five subgroups, containing 8 mice each. Group A (treatment) received Saline or Morphine for 11 days and after that they received pantoprazole (25, 50, 100 mg/kg/day) on the day 11th. Group B (prevention) received Saline or Morphine and different doses of pantoprazole half an hour before the injection of morphine (10 mg/kg, sc) for 10 days.Then, on the day 11th, after taking the baseline latency time, by injecting a dose of morphine (mg/kg, ip, morphine analgesic) hot plate test was performed in the mentioned groups. Findings: The results indicated that different doses of pantoprazole (25, 50, 100 mg/kg/day) cause a significant reduction in the development of tolerance. Moreover pantoprazole treatment reduced tolerance to the analgesic effects of morphine.Conclusion: Pantoprazole not only prevents tolerance to the analgesic effects of morphine, but also restores the established tolerance in mice. This effect is probably due to the mechanism of inhibiting P-glycoprotein and its gene expression. Further studies must be designed to clarify the exact mechanisms.
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    Evaluation of the effectes of Erythromycin and Dextromethorphan on morphine induced tolerance in mice
    (Tabriz University of Medical Sciences , School of Pharmacy, 2024) Sattari shiraz, Mohammad; habibi asl, Bohlul; Charkhpor, Mohammad
    Introduction:Several mechanisms (increasing NMDA receptors, increasing p-gp gene expression, etc.) are involved in the tolerance to the analgesic effects of morphine. Dextromethorphan is an antitussive and a p-gp substrate. On the other hand, erythromycin, is macrolide antibiotics, also has an inhibitory effect on p-gp.Aime: The aime of this study was to investigate the effects of dextromethorphan and erythromycin in the treatment of tolerance to the analgesic effects of morphine in mice.Matrial and Method:100 male mice in 10 groups of 10 in the weight range of 20-30 grams were randomly selected and given drug regimens of Saline (10 ml/kg, ip) or Morphine (25 mg/kg, ip) to develop tolerance to morphine once a day for fourteen days. Then on the fifteenth day, different doses of erythromycin (50, 100, 200 mg/kg, ip), or dextromethorphan (10, 20, 40 mg/kg, ip) and dextromethorphan (10 mg/kg, ip) + erythromycin (50 mg) /kg, ip) half an hour before the test injection of morphine (9 mg/kg, ip) was injected into the mice. Finally, the analgesic effects caused by the morphine (9 mg/kg, ip) were evaluated in the studied groups by the Hot plate method for one hour.Results & Conclusion: The results showed that different doses of dextromethorphan (10, 20, 40 mg/kg, ip) and erythromycin (50 mg/kg, ip) have a significant effect on returning tolerance to the analgesic effects caused by morphine.Also, in the combined injection of dextromethorphan (10 mg/kg, ip) + erythromycin (50 mg/kg, ip), a significant effect was observed in returning tolerance to analgesic effects.
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    Evaluation of the Effects of Cetirizine and Hydroalcoholic Extract of Green Tea on Morphine-Induced Tolerance in male mice
    (Tabriz University of Medical Sciences , School of Pharmacy, 2023) Fazli, Zahra; Asnaashari, Solmaz; Habibi asl, Bohlool; Eteraf-Oskouei, Tahereh
    Introduction:Chronic consumption of opioid analgesics leads to the development of tolerance to their pain-relieving effects. Some of the factors contribute to this tolerance including increased oxidative stress and upregulation of the P-gp gene expression.Cetirizine is an antihistamine that inhibits P-gp.Green tea extract possesses antioxidant and anti-inflammatory properties and also inhibits P-gp.Therefore, it seems that Cetirizine and green tea extract may be effective in mitigating tolerance.Objective:The aim of this study was to investigate the effects of Cetirizine and hydroalcoholic extract of green tea on morphine-induced analgesic tolerance in the male NMRI albino mice.Methods: Male mice(20-30 g, n=100)were randomly divided into 10 groups of 10 in each. They received Saline(10 ml/kg,ip) or Morphine(25mg/kg,ip) daily for 14days to induce morphine tolerance. On the 15th day, the different doses of Cetirizine(5-10-20mg/kg, ip) were administered in the 3-5groups,and hydroalcoholic green tea extract(50-100-200mg/kg,ip) in the 6-8, EXT (50mg/kg, ip) + Cetrizine (5mg/kg, ip) in the group 9 and DMSO 10% w/v in group 10, Cetirizine(10mg/kg,ip) in the group 11, half an hour before injecting the test dose of Morphine(9mg/kg,ip) in all groups.Results: Cetirizine(5-10-20mg/kg,ip) at 30 minutes and Cetirizine (10mg/kg,ip) at 45 and 60minutes have a significant effect on returning tolerance to the analgesic effects of morphine. While the injection of different doses of EXT(50-200 mg/kg, ip) did not show a significant effect in returning the tolerance to the analgesic effects caused by morphine. In the combined injection of two drugs EXT(50 mg/kg, ip) + Cetirizine(5mg/kg, ip) no significant effect was observed in returning tolerance to the analgesic effects of morphine.Conclusion: Different doses of Cetirizine increase the analgesic effects of morphine in morphine-tolerant animals. In order to obtain the exact mechanism, we need additional studies.
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    Evaluation of the effectes of atorovastatin and simvastatin on morphine induced tolerance in mice
    (Tabriz University of Medical Sciences , School of Pharmacy, 2023) banimasoud, Armin; Habibi Asl, Bohloul; Najafi, Moslem; Soraya, Hamid
    Introduction: Morphine is one of the most widely used opioid analgesic that is used to control severe pain. Tolerance to the analgesic effects of morphine is one of the problems caused by the chronic use of morphine. Several mechanisms (inhibition of NMDA receptors, increased p-gp gene expression, etc.) are involved in the emergence of tolerance to the analgesic effects of morphine. Atorvastatin and simvastatin are both from the family of statins and also they are P-glycoprotein inhibitors.Purpose: The purpose of this study was to investigate the effects of atorvastatin and simvastatin in reducing tolerance to the analgesic effects of morphine in mice. Methods: 80 male mice in 8 groups of 10 in the weight range of 20-30 grams were selected randomly and they received Saline (10 ml/kg, ip) or Morphine (25 mg/kg ip) to develop tolerance to morphine once a day for fourteen days. Then on the fifteenth day, different doses of atorvastatin (5-10-20 mg/kg, ip) in groups 3-5 and simvastatin (2.5-5-10 mg/kg, ip) in groups 6-8 were injected to the mice. The analgesic effects caused by morphine test dose (9mg/kg, ip) were evaluated by hot plate method.Results: The results showed that different doses of atorvastatin (5-10-20mg/kg, ip) did not have a significant effect on reversing tolerance to the analgesic effects caused by morphine. while significant effect of simvastatin (2.5mg/kg, ip) was effective in reversing the tolerance to the analgesic effects of morphine (P<0.01). Conclusion: Simvastatin has beneficial effects in dose of (2.5mg/kg, ip) in reversing tolerance to the analgesic effects of morphine.