School of Pharmacy

Permanent URI for this communityhttps://dspace.tbzmed.ac.ir/handle/123456789/5

The School of Pharmacy, as the second pharmacy faculty in Iran after Tehran pharmacy school in 1328 Hejri Shamsi , was located at Tabriz Imam Khomeyni square and Ayatollah Taleghani Street ,was established to provide the country needs to pharmacist. This major change occurs when there was no pharmacy school in Tabriz and pharmacy personnels learn it experimently and finally reach the stage of dispensering . Permission to establish a pharmacy was given after passing the test which requires the literacy and knowing Latin language and dispenesring. Tabriz pharmacy faculty is established after student advertising admission. At the first reception, the number of students did not pass, But college starts first training cources with 25 students. After 2-year curriculum of courses, the speciality pharmaceutical topics were teached. Toxicology and jalinoosi products were as specialized courses. Later by the dean Department , Dear doctor Ismaiil Anghajy , basic steps were taken for developing the faculty. School of Pharmacy began its own activities with medicine school and gained independence in 1345.following the dissolution of the pharmacy schools in whole country in September 1347, a new school of pharmaceutical and clinical laboratory sciences began its own activities.The pharmacy faculty was established with the aim of training pharmacy students and drug experts to manage pharmacy, Pharmaceutical industry,economy of country and training experts to work in clinical laboratory and searching in pharmacy and the laboratory. The Department of Laboratory science was transferred Medicine faculty in 1351. The Nutrition school within Tabriz Pharmacy Faculty began its academic activities with 39 students in 1353 and with the establishment of the health and nutrition school it was separated from pharmacy faculty in 1370. The new building for the School of Pharmacy started with an area of ​​17,000 square meters in 1386. Tabriz School of Pharmacy has more than 3000 pharmacy graduated is delivered to our country that many of them , have been efficient and effective rules in Pharmaceutical Science. currently Tabriz School of Pharmacy consists of 7 Department of Pharmaceutic, Pharmacology and Toxicology, Pharmacognosy, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Clinical Pharmacy and Food and Drug Control. Faculty Education departments and physical facilities with high knowledge of professors tries to through training programs, basic and applied researches and provide services , solve problems with use of a pharmacy modern knowledge and Significant contribution in scientific development of their own country. Training courses for PhD students starts in field of Pharmacognosy in Tabriz school of pharmacy . now 62 PhD students are studing in Tabriz Pharmacy faculty in the field of Pharmacognosy, Pharmaceutics, Pharmacology, Pharmaceutical Chemistry, Toxicology, Biotechnology, pharmaceutical and food and drug control. Tabriz Pharmacy school is located at the heart of the city where the science and art were born. preserved old town in the vicinity of modern development, its proximity to the Shahand mountain that always carrying snow and Uromiye lake and ... causes the city unforgettable for students who live and study in it.

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  • Item type: Item ,
    Evaluation of cytotoxicity of nano graphene quantum dots and their in vitro antifungal activity on Candida albicans and Candida glabrata
    (Tabriz University of Medical Sciences , School of Pharmacy, 2022) Farrokhi, Negin; Dilmaghani, Azita; Halajnezhadi, Somayeh; Fakhari, Ashraf
    Introduction: In recent years, attention has been paid to new drug delivery systems such as Nano medicines for the treatment of diseases. Today, nanoparticles have found wide applications. Objective: Evaluation of cytotoxicity of nano graphene quantum dots and their in vitro antifungal activity on Candida albicans and Candida glabrata.Methods: In this research, the cytotoxicity of nano graphene quantum dots on HFF2 cell line was investigated using MTT assay. In order to study the antimicrobial effect of nano quantum dot graphene, the diameter of the halo of no growth was determined. The minimum growth inhibitory concentration (MIC) was determined by serial dilution method in liquid culture medium. Next, the amount of minimum fungicidal concentration (MFC) was checked, and finally, the death time of Candida albicans and Candida glabrata cells was studied using the time kill study method.Results: Determining the diameter of the halo of non-growth showed that the effect of quantum dots against Candida albicans and Candida glabrata is less than amphotericin (as a standard) but comparable to it. The MIC for Candida albicans and Candida glabrata is 1.25 mg/cc and 6.25 mg/cc, respectively, and the MFC is 2.5 mg/cc and 25 mg/cc, respectively. The MTT test showed that with increasing amount of graphene quantum dot, its cytotoxicity for human cells also increases.Conclusion: Graphene quantum dots have good antimicrobial effects comparable to standard antifungal drugs (amphotericin) against Candida albicans and Candida glabrata. Also, the results showed that Candida glabrata is less sensitive to the antimicrobial effects of graphene quantum dots than Candida albicans. The selectivity factor for graphene quantum dots against human and fungal cells is low, and these nanoparticles, in addition to being toxic against fungi, may harm human cells as well.
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    Identification of Candida species isolated from clinical samples of neonatal and children admitted to Tabriz Children´s Hospital using PCR of rDNA-ITS in 2021
    (Tabriz University of Medical Sciences , School of Pharmacy, 2022) Mirzaee, Taraneh; Aslani, Narges; Ahangarzadeh Rezaee, Mohammad; Dilmaghani, Azita; Naghili Hokmabadi, Behrooz
    Introduction: Today, candidiasis is considered an important problem, especially among patients who are hospitalized for a long time. Although Candida albicans is the most common species isolated from colonization and candidiasis, in recent years we have witnessed the spread of infections caused by non-Candida albicans species (Candida krusei, Candida tropicalis, Candida parapsilosis, and Candida glabrata) and other yeast species with different sensitivities and even resistance to common antifungal drugs prescribed in the intensive care unit. Among the 200 identified Candida species, a small number is related to normal flora of humans and some animal species. Also 20 of species are among the apportunistic pathogens of humans and animals and they play a role in causing disease and pathological symptoms. Objective: Determining the Candida species isolated from children and infants hospitalized in different departments of Tabriz Children's Hospital using conventional and molecular methods. Methods: To identify Candida species, the samples taken from children hospitalized in different departments of Tabriz Children's Hospital were cultured in specific environments. Then after examination with microscopic methods, genotyping methods including DNA extraction, and determination of the sequence of the ITS region were performed. Results: According to the tests and investigations carried out on the samples and matching the results of cultures and microscopic examinations with the results of DNA extraction and determination of the sequence of the ITS region of 97 examined samples, we found out that 50 of isolates were related to Candida glabrata, 34 isolates related to Candida albicans or Candida Double Nensis, 5 isolates related to Candida kefir, 6 isolates related to Candida krusei, and 2 of isolates were related to Candida tropicalis. Conclusion: According to the results, the most common species among our investigated samples was Candida glabrata which indicates the change of the main Candida albicans to non-albicans type.
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    Evaluation of the physicochemical preoperties of Flocytosine nanoliposomes and their in vitro antifungal effects on candida albicans
    (Tabriz University of Medical Sciences, Faculty of Pharmacy, 2021) Diyanati, Haniyeh; Shayanfar, Ali; Baradaran, Behzad; Hallajnezhadi, Somayyeh; Dilmaghani, Azita
    Flucytosine has been approved as an antifungal drug for the treatment of systemic candidal infections, cryptococcal meningitis, fungal pneumonia, sepsis, candidal or cryptococcal urinary tract infections, and chromomycosis. Its off-label use is in the treatment of pediatric endocarditis caused by Aspergillus. Objective: The main purpose of this study was to prepare flucytosine nanoliposomes and to investigate their physicochemical properties and antifungal effects against Candida albicans and evaluate their toxicity on cervical cells via in vitro method. Flucytosine liposome formulations were prepared by mono-phase solution lyophilization. Liposomes were evaluated for particle size, zeta potential, encapsulation efficiency, cytotoxicity, stability, release, crystallography, and calorimetric properties. Also, the minimum lethal and inhibitory resistance of both free forms and flucytosine nanoliposomes on Candida albicans yeast was studied by the micro broth dilution method. Results: Flucytosine-containing nano-lipomal formulations were successfully produced. The results of physicochemical evaluations showed that nano-liposomes had an encapsulation efficiency of 51%. Cytotoxicity studies showed that nano-formulated flucytosine did not have significant toxicity at effective concentrations and finally the stability results showed that the stability of nano-formulation is temperature-dependent and refrigerator temperature has the best conditions for long-term storage. Examination of the inhibitory and lethal concentrations of flucytosine against yeasts showed that encapsulation doubled its effectiveness. Release studies showed that nano-formulated drug had slow release rate of flucytosine Conclusion: Using the modified mono-phase lyophilization method, nano-liposomes containing flucytosine can produce good encapsulation efficiencies as well as enhanced antifungal effect relative to the drug solution. Nanoliposome did not have significant toxicity at effective concentrations and had slow release rate of drug than drug sloution