School of Pharmacy

Permanent URI for this communityhttps://dspace.tbzmed.ac.ir/handle/123456789/5

The School of Pharmacy, as the second pharmacy faculty in Iran after Tehran pharmacy school in 1328 Hejri Shamsi , was located at Tabriz Imam Khomeyni square and Ayatollah Taleghani Street ,was established to provide the country needs to pharmacist. This major change occurs when there was no pharmacy school in Tabriz and pharmacy personnels learn it experimently and finally reach the stage of dispensering . Permission to establish a pharmacy was given after passing the test which requires the literacy and knowing Latin language and dispenesring. Tabriz pharmacy faculty is established after student advertising admission. At the first reception, the number of students did not pass, But college starts first training cources with 25 students. After 2-year curriculum of courses, the speciality pharmaceutical topics were teached. Toxicology and jalinoosi products were as specialized courses. Later by the dean Department , Dear doctor Ismaiil Anghajy , basic steps were taken for developing the faculty. School of Pharmacy began its own activities with medicine school and gained independence in 1345.following the dissolution of the pharmacy schools in whole country in September 1347, a new school of pharmaceutical and clinical laboratory sciences began its own activities.The pharmacy faculty was established with the aim of training pharmacy students and drug experts to manage pharmacy, Pharmaceutical industry,economy of country and training experts to work in clinical laboratory and searching in pharmacy and the laboratory. The Department of Laboratory science was transferred Medicine faculty in 1351. The Nutrition school within Tabriz Pharmacy Faculty began its academic activities with 39 students in 1353 and with the establishment of the health and nutrition school it was separated from pharmacy faculty in 1370. The new building for the School of Pharmacy started with an area of ​​17,000 square meters in 1386. Tabriz School of Pharmacy has more than 3000 pharmacy graduated is delivered to our country that many of them , have been efficient and effective rules in Pharmaceutical Science. currently Tabriz School of Pharmacy consists of 7 Department of Pharmaceutic, Pharmacology and Toxicology, Pharmacognosy, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Clinical Pharmacy and Food and Drug Control. Faculty Education departments and physical facilities with high knowledge of professors tries to through training programs, basic and applied researches and provide services , solve problems with use of a pharmacy modern knowledge and Significant contribution in scientific development of their own country. Training courses for PhD students starts in field of Pharmacognosy in Tabriz school of pharmacy . now 62 PhD students are studing in Tabriz Pharmacy faculty in the field of Pharmacognosy, Pharmaceutics, Pharmacology, Pharmaceutical Chemistry, Toxicology, Biotechnology, pharmaceutical and food and drug control. Tabriz Pharmacy school is located at the heart of the city where the science and art were born. preserved old town in the vicinity of modern development, its proximity to the Shahand mountain that always carrying snow and Uromiye lake and ... causes the city unforgettable for students who live and study in it.

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Start date: 1490

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    Identification of drug candidates against Histamine H3 receptors using drug repurposing strategy
    (Tabriz University of Medical Sciences, School of Pharmacy, 2024) Ayoubi, Arefeh; Hamzeh Mivehroud, Maryam; Sokouti, Babak
    Over the past three decades, H3 receptors have attracted considerable attention due to their involvement in basic physiological functions such as wakefulness, circadian and eating rhythms, sensory and motor functions cognition, memory and learning. H3 receptors as autoreceptors of histaminergic system regulate the release of histamine and other neurotransmitters in the central nervous system. Blocking of centrally localized H3 receptors would enhance the level of histamine and other neurotransmitters in the brain. Therefore, H3 receptors are considered as potential therapeutic target in neuropsychiatric disorders. Aim:The purpose of the current study was to identify drug candidates against H3 receptors using drug repurposing strategy.Materials and Methods:In the current investigation, a combination of ligand- and structure-based methods were applied for identification of approved drugs against H3 receptors based on repurposing strategy. First, a QSAR model was generated using compounds with H3 antagonistic activity. Then, the developed QSAR model was utilized for predicting antagonistic activity of FDA-approved drugs. Therapeutic agents with higher predicted potencies were carefully scrutinized based on physicochemical and pharmacokinetic, drug-likeness, as well as medicinal chemistry properties. Drugs with desired properties were subjected to molecular docking and dynamics simulation for investigation of binding mode and affinity of the ligands towards H3 receptor using GOLD and AMBER programs. Molecular Mechanics (MM)-Poisson-Boltzmann Surface Area (PBSA)/Generalized-Born Surface Area (GBSA) methodologies implemented in AMBER package were applied for calculation of binding free energies. Results:Among the FDA-approved drugs, six drugs were introduced as the most suitable candidates in terms of predicted H3 antagonistic activity as well as pharmacokinetic and drug-likeness features. Conclusion:The results of the current study can offer some approved drugs to be useful in neuropsychiatric disorders. However, more preclinical bioassays both in in vitro and in vivo platforms are required to verify the in silico predictions.
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    Target Prediction for DMARDs as anti-Alzheimer’s Drugs
    (Tabriz University of Medical Sciences, School of Pharmacy, 2025) Khalilpour, Hadi; Soltani, Somaieh; Wolber, Gerhard
    Introduction: Chronic inflammation is a common feature in various autoimmune disorders and neurological diseases, particularly Alzheimer's disease. The role of anti-inflammatory agents, such as disease-modifying antirheumatic drugs (DMARDs), has garnered attention due to their potential to reduce neuroinflammation. New evidence suggests that patients undergoing treatment with DMARDs, especially those using biological agents, may have a reduced risk of developing dementia or Alzheimer's disease. This connection highlights the importance of exploring DMARDs as a therapeutic approach for neurological conditions. Objective: Target Prediction for DMARDs as anti-Alzheimer’s Drugs.Methods: Initially, a comprehensive database for DMARD compounds was created using the KEGG database and literature searches. Additionally, potential Alzheimer's targets were gathered from previous research and related databases. Target predictions were made using a developed ChEMBL model and a similarity-based fingerprinting method, with the Proba score calculated for each prediction using the Naive Bayes algorithm. Finally, predicted targets with a score higher than 0.9 were selected and ranked based on in vivo and in vitro experimental evidence regarding the relationship between the predicted target and the corresponding ligand, as well as similar results from online prediction systems. Higher-ranked targets were chosen for ligand-target interaction studies using molecular docking. Python scripts were developed to execute the target prediction process for the ligands.Results: From an initial set of 90 compounds in the DMARDs database, targets for 25 of them were predicted for various Alzheimer's targets. By combining evidence-based results with findings from online target prediction systems, the predicted targets were ranked. Ultimately, two targets, JNK3 and VEGFR-2, were selected for molecular docking studies.Conclusion: The results of this study support the potential repurposing of DMARDs in the treatment of neurodegenerative diseases such as Alzheimer's. Furthermore, the predictive model developed in this research offers a valuable tool for identifying potential Alzheimer's targets for additional lead compounds, paving the way for future exploration and therapeutic innovation in this critical area of medicine.
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    Use of gold/iron metal-organic framework nanoparticles (AuNPs/FeMOF)-modified glassy carbon electrode as an electrochemical sensor for the quantification of risperidone in patient plasma samples
    (Tabriz University of Medical Sciences, School of Pharmacy, 2025) pashanejad, Haniyeh; Farjami, Afsaneh; Ranjbar, Fatemeh; Jouyban, Abolghasem; Soleymani, Jafar
    Introduction: Neuropsychiatric diseases are usually accompanied by lifelong disabilities, which brings those disabilities a heavy economic burden. Risperidone (RIS) is approved for the treatment of schizophrenia. Recommended serum therapeutic reference for RIS ranges from 20 to 60 ng/mL combined with RIS and 9-hydroxyrisperidone (an active metabolite) serum concentration. Moreover, RIS is the most evidence-supported atypical antipsychotic, indicating a direct correlation between serum concentration and pharmacological effects, and levels above 120 ng/mL are associated with adverse effects like the development of Parkinsonian symptoms and hyperprolactinemia. So, therapeutic drug monitoring (TDM) is considered a true-of-certain concept that reflects the regulation of efficacy and incidence of severe side effects in patients with RIS therapeutic regimens.Goal: In this research work, an electrochemical sensor was fabricated for the determination of risperidone in human plasma samples based on gold/iron metal-organic framework nanoparticles on the glassy carbon electrode.Methods: This paper is provided to develop an electrochemical probe for the determination of RIS in biological samples by modification of a glassy carbon electrode (GCE) using gold nanoparticles (AuNPs) and iron metal-organic frameworks (FeMOFs). The electrochemical behavior was studied using cyclic voltammetry (CV) and square wave voltammetry (SWV).Results: The peak current increases beyond the addition of AuNPs and FeMOFs due to the dual amplification mechanism. So, the modification of the GCE surface improves the electrochemical activity compared with a bare electrode.Conclusions: The proposed method, with further validation and testing in more real samples, can be used as a reliable method for measuring RIS in clinics. Also, due to its high sensitivity and selectivity, and the use of relatively inexpensive materials in the preparation of the probe, it can be commercially available as a screen-printed electrode for fast and reliable detection of RIS after proper validations.
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    Quantitative structure-activity studies on H4 receptor antagonists
    (Tabriz University of Medical Sciences, School of Pharmacy, 2025) Foroutan Rad, Sara; Hamzeh Mivehroud, Maryam; Dastmalchi, Siavoush
    Introduction:The drug development is considered as one of the most complex and costly process in pharmaceutical sciences. Application of computational techniques in this context can accelerate the identification of novel ligands by reduction of time and costs. One of the commonly used methods in this field is QSAR modeling, which investigates the relationship between the structural features of compounds and their biological activities. Among the histamine receptors, H4 receptor has gained much attention in recent years due to its significant role in inflammatory, allergic, and autoimmune diseases. There are several lines of evidence indicating therapeutic benefits of H4 receptor antagonists in treatment of such diseases.Objective:The objective of this study was to generate a reliable 3D-QSAR model for prediction of biological activity of H4 antagonists and investigation of key interactions between studied compounds and H4 receptor.Methods:In this study, alignment-independent 3D-QSAR modeling method was developed. A database consists of 77 compounds was collected from literature. Following the geometric optimization of the molecular structures using HyperChem program, QSAR modeling was carried out with Pentacle software. The obtained model was statistically evaluated for estimation of its predictive capability. Results:Statistical analysis of the data using PLS method showed that the final model had a correlation coefficient of R² equal to 0.84 and the internal and external validation correlation coefficients were 0.55 and 0.6, respectively. Moreover, Y-scrambling validation tests indicated the absence of chance correlation in the developed model.Conclusion:In this work, the most important features needed for antagonistic activity of triazine and pyrimidine derivatives were identified indicating importance of hydrogen bond and hydrophobic interactions in the complex of ligand-receptor. The results of this study can be used in designing of potent H4 antagonists where blockade of H4 receptors is required.
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    Design and synthesis of new derivatives of the 1,3,5-triazine-isatin Schiff base as anti-Alzheimer compounds
    (Tabriz University of Medical Sciences, School of Pharmacy, 2025) Tamaddon Abibigloo, Yasaman; Jadidi, Khosrow; Razzaghi Asl, Nima; Shahbazi Mojarrad, Javid; Dastmalchi, Siavoush
    Introduction: Alzheimer's disease is known as an irreversible neurodegenerative disease that mostly affects elderly people. Since several factors are involved in the process of this disease, the compounds directed to several targets are considered as beneficial compounds for its control. Isatin and 1,3,5-triazine are compounds with different biological effects and their different derivatives had anti-Alzheimer effects.Aims: The aim of this research was to design, synthesize and biological evaluations of the isatin-1,3,5-triazine-aniline/benzylamine hybrids as multi-target directed ligand against Alzheimer's disease. Methods: In this thesis the two groups of isatin-1,3,5-triazine-aniline 8(a-o) and isatin-1,3,5-triazine-benzylamine 8(p-z) derivatives were designed and synthesized. These molecules were evaluated as multi-target directed ligand that inhibit the cholinesterase enzymes, have antioxidant effects and could chelate to biometal ions, which Ellman’s colorimetric assay, the DPPH method, and the UV-Vis method was used in order to check these properties, respectively. Auto dock 4.2 software was used to investigate the mode of interaction between the compounds and the active site of cholinesterase enzymes.Results: The designed compounds were synthesized by different methods and their final structure confirmed by 1H, 13CNMR, IR and mass spectrometry methods. The range of molecules IC50 for acetylcholinesterase and butyrylcholinesterase enzymes were 0.2-734.5nM and 0.02-3.88μM, respectively. The compounds with hydroxy group had acceptable antioxidant effects. Changes in the compounds and biometal ions mixture UV-Vis spectrum confirmed these compounds have a good ability to form complexes with the studied ions. Molecular docking studies confirmed these compounds have effective interactions with the active site residues of the acetyl/butyrylcholinesterase enzymes.Conclusion: The results showed this study molecules are good scaffolds as multi-target directed ligands for Alzheimer's disease, and have good potential for optimization and further investigations as lead compounds.
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    Determining the insidence of drug-induced AKI in children admitted to PICU a cross sectional study
    (Tabriz University of Medical Sciences, School of Pharmacy, 2025) Shafi pour, Samira; Sarbakhsh, Parvin; Gharekhani, Afshin; Jafari Rouhi, Amirhosein; Seldouzian, Mohammad
    Introduction: Acute kidney injury (AKI) can have significant consequences in the clinical management of hospitalized patients. Identifying drugs responsible for AKI may lead to the use of safer pharmacologic alternatives in patient care.Objective: To evaluate the incidence of drug-induced AKI in children admitted to the Pediatric Intensive Care Unit (PICU): a prospective observational cross-sectional study.Methods: This was an observational cross-sectional study conducted on children admitted to the PICU of Zahra Mardani Azar Children’s Hospital in Tabriz during the year 2022 (1401 in the Iranian calendar) over a 12-month period. Data sources included the patients’ medication charts, medical records, and nursing notes. Patient information was extracted from the medical records, and all administered medications were comprehensively documented.Results: The incidence of AKI among children admitted to the PICU was 13 patients (6.3%). Of these, 4 cases (30.76%) were diagnosed with drug-induced AKI, and 9 cases (69.23%) with non-drug-related AKI. Analysis of prescribed medications revealed a statistically significant difference between the AKI and non-AKI groups with regard to certain drugs. Notably, iodinated contrast media (P < 0.0001), antiviral agents (P < 0.0001), furosemide (P < 0.0001), and ceftriaxone (P = 0.018) were significantly associated with the development of AKI.Conclusion: The incidence of acute kidney injury (AKI) among children admitted to the PICU was 6.3%. Of these, 30.76% were drug-induced AKI cases, while 69.23% were non-drug-related. The study highlights that certain medications, particularly iodinated contrast agents, antiviral drugs, furosemide, and ceftriaxone, are significantly associated with the occurrence of AKI in pediatric patients. These findings underscore the importance of cautious prescription and monitoring of nephrotoxic agents in critically ill children.
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    Evaluation of the effect of pentoxifylline and natural honey on morphine dependence in mice
    (Tabriz University of Medical Sciences, School of Pharmacy, 2025) Rabiei, Erfan; Habibi Asl, Bohlool; Najafi, Moslem
    Introduction: In the process of forming dependence and tolerance to opioids, various mechanisms such as increased oxidative stress, increased activity of the glutaminergic system, etc. are observed. Pentoxifylline and natural honey are among the drugs with antioxidant properties. Aim: The purpose of this study was evaluation the effect of pentoxifylline and natural honey on morphine dependence in mice.Methods: 90 male mice in 9 groups of 10 in the weight range of 20-30 g were randomly selected and received the following medication regimens once a day for two weeks. 1-Saline (10ml/kg,ip) +Saline (10ml/kg,ip) 2-Saline (10ml/kg,ip) + Morphine (25mg/kg,ip) 3,4,5- pentoxifylline (20,40,80mg/kg,ip) + Morphine (25mg/kg,ip) 6,7,8-Natural Honey (100,200,400mg/kg,ip) + Morphine (25mg/kg,ip) 9- pentoxifylline (20mg/kg,ip) + Honey (100mg/kg,ip) + Morphine (25mg/kg,ip) On the fourteenth day, naloxone (4mg / kg, ip) was injected into animals two hours after morphine injection and withdrawal symptoms were measured within half an hour. Finally, to measure serum MDA and TAC levels in different groups, the animals were anesthetized and blood samples were taken from the heart.Results: The results showed that intraperitoneal injection of honey in 3 doses (100, 200 and 400 mg/kg) and pentoxifylline with a dose of (20, 40, 80 mg/kg) each alone causes a significant reduction in the symptoms of morphine dependence.Conclusion: The findings of our study showed that the chronic consumption of honey in a non-dose-dependent manner and pentoxifylline in a dose-dependent manner had a beneficial effect in reducing the symptoms of morphine withdrawal syndrome and this effect is probably related to the anti-inflammatory properties of flavonoids in Honey and the antioxidant effects of pentoxifylline.
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    Preparation of self-nano emulsifying drug delivery system (SNEDDs) of buprenorphine and evaluation of its analgesic effect on mice
    (Tabriz University of Medical Sciences, School of Pharmacy, 2024) Ab Kharabat, Setareh; Charkhpour, Mohammad; Islambulchilar, Mina; Islambulchilar, Ziba
    Introduction: Increased absorption and lymphatic transport of drugs after loading in lipid drug delivery systems such as self-emulsifying systems can also increase oral bioavailability. Objective: In this project, the analgesic effect of Self-Nanoemolsifying Drug Delivery Systems containing the drug buprenorphine was investigated in male albino mice.Methods: In this study, the best SNEDDS formulation with the best solubility was selected and loaded with buprenorphine. 7 groups of 10 male albino mice weighing 20 to 25 grams were included in this study. The grouping was as follows: 1) SNEDDS formulation without buprenorphine , 2) 0.25 mg/kg formulation, 3) 0.5 mg/kg formulation, 4) 1 mg/kg formulation, 5) 0.25 mg/kg of pure drug powder, 6) 0.5 mg/kg of pure drug powder, 7) 1 mg/kg of pure drug powder. The analgesic effect of the drugs was investigated using the hot plate test with a temperature of 54 degrees. Data were analyzed using GraphPad software and One Way ANOVA test.Results: The findings showed that the formulation prepared in all time intervals and in all doses had a longer tolerance period in the hot plate test than the drug powder (p < 0.001). The amount of tolerance of mice in the hot plate test in the second group increased with the passage of time from 1 to 3 hours, and in the case of groups 3 and 4, it decreased significantly (p < 0.05). Also, the average percentage of mpe in all doses in the prepared formulation was significantly higher than the powder (p < 0.001). Conclusion: Based on the findings of this study, the nanoemolsifiable formulation of buprenorphine has better analgesic effects than the powder of the drug itself in doses of 0.25, 0.5, and 1 mg/kg, as well as time intervals of 0.5, 1 and It was 3 hours.
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    Evaluation of the effects of clarithromycin on renal toxicity of cisplatin in male mice
    (Tabriz University of Medical Sciences, School of Pharmacy, 2025) Hosseinzadeh, Mahdi; Habibi Asl, Bohlul; Tayebi Khosroshahi, Hamid; Pourlak, Tala; Mohajjel Nayebi, AliReza
    Introduction: One major adverse effect of cisplatin that restricts its use in cancer patients is nephrotoxicity. Reducing cisplatin nephrotoxicity, the primary adverse effect of this medication, is therefore crucial. This work is significant because clarithromycin can stop the generation of proinflammatory factors that are created in the cisplatin toxicity pathway.Aim: Analyzing how clarithromycin affects male mice's renal damage from cisplatin.Methods: Five groups of 10 male mice weighing 20-30 g received the following drug regimens for 9 days: Group 1: Control solution with a dose of DMSO 10 ml/kg, SC + Saline 10 ml/kg, IP. Group 2: Control solution with a dose of DMSO 10 ml/kg, SC. Group 3: Clarithromycin solution 25 mg/kg/day, SC. Group 4: Clarithromycin solution 50 mg/kg/day, SC. Group 5: Clarithromycin solution 100 mg/kg/day, SC. Then, on the 6th day, a single dose of 20 mg/kg of cisplatin was injected IP into groups 2 to 5. After 3 days, the animals underwent surgery with ketamine and xylazine and were evaluated for serum urea and creatinine levels and histopathology of kidney tissue.Results: Receiving different doses of clarithromycin was effective in preventing acute kidney injury caused by cisplatin, and part of this effect may be related to the inhibitory effects of a transcription factor called NF-κB. It is also possible that clarithromycin prevented cisplatin-induced acute kidney injury by inhibiting intracellular oxidative stress pathways.Conclusion: In fact, when mice received clarithromycin, the amount of kidney tissue damage in mice receiving cisplatin was significantly reduced.
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    Evaluation of the effect of dextromethorphan and bupropion in reversing morphine-induced tolerance in mice
    (Tabriz University of Medical Sciences, School of Pharmacy, 2025) Hemmaty Pour, Sina; Habibi Asl, Bohlool; Charkhpour, Mohammad; Parvizpur, Alireza
    Introduction: Changes in the function of glutamatergic, dopaminergic and adrenergic systems are among the changes that occur in chronic morphine use. Dextromethorphan is an antitussive and has inhibitory effects on NMDA receptors. Bupropion, as an antidepressant, inhibits the metabolism of dextromethorphan and increases its release into the CNS. Aim: The aim of the study was to evaluate the effect of dextromethorphan and bupropion in the treatment of morphine-induced tolerance in mice. Material & Method: several mices (11 groups, 10 in each, 20-30g) were randomly selected for the following regimens for 17 days: 1. Saline (10ml/kg, 1st-17th days, S.C.) + Saline (10ml/kg, 11th-17th days, S.C.) 2. Morphine (10mg/kg, 1st-17th days, S.C.) + Saline (10ml/kg, 11th-17th days, S.C.) 3, 4, 5. Morphine (10mg/kg, 1st-17th days, S.C.) + Dextromethorphan (15,30,60 mg/kg/12h, 11th-17th days, S.C.) 6, 7, 8. Morphine (10mg/kg, 1st-17th days, S.C.) + Bupropion (40,80,110 mg/kg/12h, 11th-17th days, S.C.) 9, 10, 11. Morphine (10mg/kg, 1st-17th days, S.C.) + Dextromethorphan (15,30,60 mg/kg/12h, 11th-17th days, S.C.) + Bupropion (110,80,40 mg/kg/12h, 11th-17th days, S.C.). once on day11 and once on day17, the hotplate test was performed by injecting a test-dose morphine (9mg/kg) to animals. Results: Injection of dextromethorphan (15mg/kg) and bupropion (80mg/kg and 110mg/kg) and co-injection of dextromethorphan (15mg/kg) and bupropion (110mg/kg) accelerated tolerance compared to S+M group. However, in the injection of bupropion (40mg/kg) and co-injection of dextromethorphan (60mg/kg) and bupropion (40mg/kg), we observed a delay in tolerance compared to S+M group. Significant changes were also observed in MDA and TAC levels in bupropion (mg/kg 40) and dextromethorphan (60mg/kg) and bupropion (40mg/kg) groups compared to S+M group. Conclusion: The co-injection of dextromethorphan (60mg/kg) and bupropion (40mg/kg) and use of bupropion (40mg/kg) seem to be suitable for delaying tolerance to morphine; further studies are needed to observe precise mechanisms.