School of Pharmacy

Permanent URI for this communityhttps://dspace.tbzmed.ac.ir/handle/123456789/5

The School of Pharmacy, as the second pharmacy faculty in Iran after Tehran pharmacy school in 1328 Hejri Shamsi , was located at Tabriz Imam Khomeyni square and Ayatollah Taleghani Street ,was established to provide the country needs to pharmacist. This major change occurs when there was no pharmacy school in Tabriz and pharmacy personnels learn it experimently and finally reach the stage of dispensering . Permission to establish a pharmacy was given after passing the test which requires the literacy and knowing Latin language and dispenesring. Tabriz pharmacy faculty is established after student advertising admission. At the first reception, the number of students did not pass, But college starts first training cources with 25 students. After 2-year curriculum of courses, the speciality pharmaceutical topics were teached. Toxicology and jalinoosi products were as specialized courses. Later by the dean Department , Dear doctor Ismaiil Anghajy , basic steps were taken for developing the faculty. School of Pharmacy began its own activities with medicine school and gained independence in 1345.following the dissolution of the pharmacy schools in whole country in September 1347, a new school of pharmaceutical and clinical laboratory sciences began its own activities.The pharmacy faculty was established with the aim of training pharmacy students and drug experts to manage pharmacy, Pharmaceutical industry,economy of country and training experts to work in clinical laboratory and searching in pharmacy and the laboratory. The Department of Laboratory science was transferred Medicine faculty in 1351. The Nutrition school within Tabriz Pharmacy Faculty began its academic activities with 39 students in 1353 and with the establishment of the health and nutrition school it was separated from pharmacy faculty in 1370. The new building for the School of Pharmacy started with an area of ​​17,000 square meters in 1386. Tabriz School of Pharmacy has more than 3000 pharmacy graduated is delivered to our country that many of them , have been efficient and effective rules in Pharmaceutical Science. currently Tabriz School of Pharmacy consists of 7 Department of Pharmaceutic, Pharmacology and Toxicology, Pharmacognosy, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Clinical Pharmacy and Food and Drug Control. Faculty Education departments and physical facilities with high knowledge of professors tries to through training programs, basic and applied researches and provide services , solve problems with use of a pharmacy modern knowledge and Significant contribution in scientific development of their own country. Training courses for PhD students starts in field of Pharmacognosy in Tabriz school of pharmacy . now 62 PhD students are studing in Tabriz Pharmacy faculty in the field of Pharmacognosy, Pharmaceutics, Pharmacology, Pharmaceutical Chemistry, Toxicology, Biotechnology, pharmaceutical and food and drug control. Tabriz Pharmacy school is located at the heart of the city where the science and art were born. preserved old town in the vicinity of modern development, its proximity to the Shahand mountain that always carrying snow and Uromiye lake and ... causes the city unforgettable for students who live and study in it.

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  • Item type: Item ,
    Application of Graphene Quantom dot on determination of ِDoxorubicin on biological samples
    (Tabriz University of Medical Science, School of pharmacy, 2015) Hashemzadeh, Nastaran; Jouyban, Abolghasem; Shadjou, Nasrin
    Introduction: Nowadays anticancer drugs which used as chemotherapy regimen for patients are become more useful. The development of an accurate and repeatable method for determination of these drugs, will improve our understanding of their role in the treatment process. One of the common methods of determining the trace amount of these drugs is electrochemical methods. According to the importance of these methods in the analysis of drugs, in the present study graphene quantum dots (GQDs) used as active ingredient in the preparation of electrochemical sensors. Application of prepared electrochemical sensor for the detection and quantification of doxorubicin in biological samples were studied. Aim: Developing an electrochemical sensor based on graphene quantum dots and its application for the detection and determination of doxorubicin (DOX) in biological samples. Methods: In this study, GQDs were synthesized by pyrolyzing citric acid in alkaline solution.The UV–Vis spectroscopy, X-ray diffraction (XRD), transition electron microscopy (TEM), Fourier transform infrared (Ft-IR) spectroscopy, Atomic force microscopy (AFM) and cyclic and differential pulse voltammetric techniques were used for characterizing synthesized GQDs. The electrochemical behavior of GQD modified glassy carbon electrode (GQD-GCE) was studied using cyclic voltammetry (CV) technique. The electrochemical behavior of DOX was investigated at the GQD-GCE in phosphate buffer solution (PBS), using differential pulse voltammetry technique (DPV). Results and Conclusion: electrochemical behavior GQD-GCE was studied using CV and DPV. DPV was used to evaluate the analytical performance of DOX in the presence of PBS (pH 4) and good limit of detection was obtained by proposed sensor. The results revealed that GQD promotes the rate of oxidation by increasing the peak current. Finally, the applicability of the proposed method was described to the direct assays of spiked human plasma.
  • Item type: Item ,
    Targeted therapy of breast cancer using methotrexate and indolamine-2,3-dioxygenase inhibitor loaded mesoporous silica magnetic nanoparticles
    (Tabriz University of Medical Sciences, Faculty of Pharmacy, 2021) Hashemzadeh, Nastaran; Omidi, Yadollah; Barzegar Jalali, Mohammad; Aghanezhad, Ayoub; Barar, Jaleh; Adibkia, Khosro
    Introduction: Conventional cancer therapeutic agents often are associated with the serious challenge due to adverse effects. Whereases, the emergence of targeted drug delivery vehicles provides an alternative approach for cancer therapy. Recently, cancer immunotherapy agents such as 1-Methyl-D Tryptophan (1-MDT) have been mostly used in cancer therapy. Aim: We established the PEGylated targeted drug delivery system using mesoporous silica magnetic nanoparticles (MSMNPs) for encapsulating 1-Methyl-D Tryptophan (1-MDT) as an immunotherapeutic and investigated its anti-tumor efficiency in combination with methotrexate (MTX) on breast cancer cell lines. Methods: In the present study, the thermal decomposition technique was used to synthesize superparamagnetic iron oxide nanoparticles (SPIONs). In the next step, these SPIONs were coated with mesoporous silica and conjugated with Polyethylene glycol (PEG) 2100 polymer and methotrexate in various steps to achieve MTX-PEG-MSMNPs. Subsequently, 1-MDT was loaded onto the final particles. Prepared NPs were characterized beyond each synthetic step using TEM, SEM, DLS, ATR-FTIR, VSM, BET, and XRD. Thereupon, quantitative RT- PCR was used to investigate the effect of 1-MDT on the expression of indoleamine 2,3 dioxygenase (IDO) on cancer cells. Besides, flow cytometry was performed to evaluate the cellular uptake. Subsequently, the antiproliferative effect of NPs was explored using MTT, NIR, and apoptosis assays in cancer cells. Results: The results revealed that the MTX-PEG-MSMNPs had a uniform size distribution (average size = 68.33, PDI=0.16). The Encapsulation efficiency and Loading capacity respectively were about 71% and 60%. Uptake experiments demonstrated that prepared nanoparticles can target breast cancer cells. RT-PCR data indicated that 1-MDT suppressed the IDO level. Besides, cytotoxic and apoptosis assays further confirmed the efficiency of NPs in cancer cell growth inhibition. Moreover, in-vitro MTT analysis revealed that 1-MDT loaded in MTX-PEG-MSMNPs in combination with NIR declined the cell viability. Conclusion: Overall, the engineered PEGylated MTX- armed mesoporous silica magnetic nanoparticles had potential anti-tumor impacts in vitro.
  • Item type: Item ,
    Application of Graphene Quantom dot on determination of ِDoxorubicin on biological samples
    (Tabriz University of Medical Sciences, School of Pharmacy, 2015) Hashemzadeh, Nastaran; Jouyban, Abolghasem; Shadjou, Nasrin
    Introduction: Nowadays anticancer drugs which used as chemotherapy regimen for patients are become more useful. The development of an accurate and repeatable method for determination of these drugs, will improve our understanding of their role in the treatment process. One of the common methods of determining the trace amount of these drugs is electrochemical methods. According to the importance of these methods in the analysis of drugs, in the present study graphene quantum dots (GQDs) used as active ingredient in the preparation of electrochemical sensors. Application of prepared electrochemical sensor for the detection and quantification of doxorubicin in biological samples were studied. Aim: Developing an electrochemical sensor based on graphene quantum dots and its application for the detection and determination of doxorubicin (DOX) in biological samples. Methods: In this study, GQDs were synthesized by pyrolyzing citric acid in alkaline solution.The UV–Vis spectroscopy, X-ray diffraction (XRD), transition electron microscopy (TEM), Fourier transform infrared (Ft-IR) spectroscopy, Atomic force microscopy (AFM) and cyclic and differential pulse voltammetric techniques were used for characterizing synthesized GQDs. The electrochemical behavior of GQD modified glassy carbon electrode (GQD-GCE) was studied using cyclic voltammetry (CV) technique. The electrochemical behavior of DOX was investigated at the GQD-GCE in phosphate buffer solution (PBS), using differential pulse voltammetry technique (DPV). Results and Conclusion: electrochemical behavior GQD-GCE was studied using CV and DPV. DPV was used to evaluate the analytical performance of DOX in the presence of PBS (pH 4) and good limit of detection was obtained by proposed sensor. The results revealed that GQD promotes the rate of oxidation by increasing the peak current. Finally, the applicability of the proposed method was described to the direct assays of spiked human plasma.