School of Medicine
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The Faculty of Medicine is one of the premier medical research and educational institutions in Iran for over 50 years.As a fist type institution in Iran, the faculty provides best educational and research programs in the areas of health and life sciences through an expert staff and province-wide model. Our faculty members, students, staff and alumni are actively engaged in leading edge research, education and community service on university and hospital campuses across the province....
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Item type: Item , Study of the frequency of TTV, TTMV, TTMDV, and TTV-specific miRNAs in patients with COVID-19 and a healthy control group in Tabriz in 1402(Tabriz University of Medical Sciences, Faculty of Medicine, 2025) Sabbaghian, Mohammad; Bannazadaeh Baghi, Hossein; Hasani, Alka; Ghotaslou, Reza; Poortahmasebi, Vahdat; Ahangar Oskouee, MahinThe relationship between human anelloviruses (AVs) and the host's immune status has been recently noticed. Infection with other pathogenic viruses, including SARS-CoV-2, can affect the frequency of AVs. The effect of increased replication of these viruses and the presence of their miRNAs on the viral infection of COVID-19, which can indicate immune system suppression, is still unclear. Materials and Methods: In this case-control study, 210 people were included, including 2 groups of patients with COVID-19 and healthy people. People with COVID-19 were divided into severe and mild categories according to the severity of the disease. Two plasma and respiratory samples were taken from each person and measured for the presence of human anellovirus DNA. At the end, the plasma samples of COVID-19, which were positive for the presence of TTV DNA, were measured for the presence of TTV miRNAs. Results: TTV DNA was significantly higher in severe cases (27.1% in plasma) compared to healthy cases (11.4%) with p-value (0.048). However, other findings among TTMV, TTMDV, and TTV miRNAs in plasma and respiratory samples showed no statistical significance, indicating no clear association between viral markers and the severity of COVID-19.Item type: Item , Prone Positioning Effect on oxygenation, ICU admission , survival and mortality in Awake Non-Intubated Severe COVID-19 Patients with Hypoxemic Respiratory Failure: an Umbrella Review of Systematic Reviews and Meta-Analysis(Tabriz University of Medical Sciences, Faculty of Medicine, 2024) Fereidouni, Fatemeh; Tahsini Tekantapeh, Sepideh; Ghojazadeh, Morteza; Soleimanpour, HassanProne positioning (PP) is a low-cost method with minimal risk to the patient that improves the oxygenation of patients with acute hypoxic respiratory failure (AHRF) due to COVID-19 pneumonia, thereby reducing their need for tracheal intubation (TI) and transferring to the intensive care unit (ICU). We aimed to overview the results of all previous systematic reviews and meta-analyses to examine the net effect of PP on oxygenation, the rate of TI and mortality in COVID-19 patients. Methods: We searched PubMed, Scopus, Web of Science, Google Scholar, and Cochrane Library databases from December 2019 through 2022 without publication language restriction for systematic reviews and meta-analysis studies on PP vs. supine position (SP) in conscious patients with hypoxic respiratory failure COVID-19. After study selection, data were extracted from published meta-analyses and pooled by comprehensive meta-analysis (CMA) software version 2.2.064 to achieve effect sizes. They were analyzed for TI and mortality rates dichotomous variables, and the results were shown as pooled odds ratios (OR) with a 95% confidence interval (CI). Continuous variables such as oxygenation indices (PaO2/FiO2 and SpO2) were also analyzed, and the data were shown as mean differences (MD) with lower and upper CI. The level of statistical significance was set at p ≤ 0.05. Results: Twelve systematic reviews and meta-analyses with 19,651 patients and six systematic reviews with 2,911 patients were included in this Review of Reviews (total: 22,562). PP treatment significantly reduced the rate of TI (OR = 0.639, %95 CI (0.492, 0.829); P-value = 0.001) and decreased mortality (OR = 0.363, %95 CI (0.240, 0.549), P-value < 0.001). There was no difference in PaO2/FiO2 (MD = 3.591[- 40.881, 48.062]; P-value = 0.874) and SpO2 percent (MD = 1.641[- 4.441, 7.723]; P-value = 0.597).Item type: Item , Adaptation of COVID-19 Stress Scale (CSS-19) in Iran(Tabriz University of Medical Sciences, Faculty of Medicine, 2024) Nikjoo, Amin; Heydari, Fariba; Norouzi, SanazIn addition to physical consequences and high mortality rate of Covid19, its psychological and social consequences have also been subject to many studies around the world. Numeral tools having been developed for this purpose; CSS-19 is one of the most cited scales. Considering the lack of a validated and reliable tool for assessment of psychosocial aspects of Covid19 in Iran, we conducted this study to adapt CSS-19 so it is suitable to be used in Iran. Methods and Materials: After Forward-Backward translation to Farsi, the questionnaire was both qualitatively and quantitatively assessed by the experts panel regarding content, construct and face validity. Then the modified Farsi CSS was filled by 50 participants twice with a 2-week interval in order to assess reliability and consistency. Results: Based on the opinions of experts panel, 16 items were deleted from Farsi CSS, including all items of Xenophobia subscale, for it to be suitable for Iranian society. Then the modified 20-item Farsi CSS was assessed by a second experts panel, which confirmed its validity. Finally, our statistical analysis showed a Cronbach`s Alfa of 0.91 and 0.88 and ICC of 0.98 for the 20-item Farsi CSS.Item type: Item , The Effect of Supplementation with boron-containing compounds and Oleoylethanolamid on Patients with Known COVID-19: pilot study(Tabriz University of Medical Sciences, Faculty of Medicine, 2022) Akbari, Neda; Teymouri, Soheil; Mobbaseri, Majid; Ostadeahimi, AlirezaAmong the common supplements, boron and oleylethanolamide compounds can be effective in the treatment of COVID-19 patients due to their anti-inflammatory effects and protease enzymes, along with routine treatments. Considering the health properties of boron and oleylethanolamide and the lack of studies in this field, the present study has been designed with the aim of investigating the supplemental effect of compounds containing boron and oleylethanolamide on the recovery rate of patients with COVID-19. Materials and Methods: This study was conducted as a randomized clinical trial in Imam Reza Hospital (Tabriz University of Medical Sciences) during 2020. In this study, 40 adult patients diagnosed with covid-19 underwent intervention. The patients were randomized into 4 treatment groups by random allocation method 1:1:1:1: (group A) 5 mg boron citrate twice a day, (group B) 200 mg oleethanolamide twice a day, (group C) They received both treatments, or (group d) routine treatments without any study drugs. Some clinical and biochemical parameters were examined before and after the intervention. Results: Supplementation with boron citrate alone or in combination with oleoylethanolamide significantly improved O2 saturation and respiratory rate (p < 0.01). At the end of the study, significant increases in white blood cell and lymphocyte count were observed in the boron citrate and combined groups (p < 0.001). Boron citrate supplementation led to a significant decrease in serum lactate dehydrogenase (p = 0.026) and erythrocyte sedimentation rate (p = 0.014), compared with other groups. Furthermore, boron citrate in combination with oleoylethanolamide resulted in a significant reduction in the high-sensitivity C-reactive protein and interleukin-1β concentrations (p = 0.031 and p = 0.027, respectively). No significant differences were found among four groups post-intervention, in terms of hemoglobin concentrations, platelet count, and serum interleukin-6 levels. At the end of the study, common symptoms of COVID-19 including cough, fatigue, shortness of breath, and myalgia significantly improved in the supplemented groups, compared to the placebo (p < 0.05).Item type: Item , Evaluation of satisfaction in undergraduate medical students of Tabriz University of Medical Sciences about virtual education in 1399-1400(Tabriz University of Medical Sciences, Faculty of Medicine, 2024) Amoozadeh, Maryam; Ghaffarifar, Saeedeh; Zare Nahandi, Maryam; Banagozar, AliMedical education at medical universities, including Tabriz University of Medical Sciences, was impacted by the COVID-19 pandemic, leading to the use of virtual education as a means to continue educational activities. This study examines medical students' satisfaction with virtual education during the pandemic and their willingness to continue this mode of education. Methods: In this exploratory study, a questionnaire was developed and psychometrically evaluated. After reviewing literature and sharing insights from experts, the questionnaire was designed with multiple-choice and open-ended questions. Validity and reliability were assessed using responses from medical education specialists. Validity was confirmed with Impact Score=4.78, CVR=0.91, and CVI=0.99. Internal consistency of the questionnaire items was measured with a Cronbach's alpha of 0.83, and stability of results was confirmed through a test-retest method involving a random sample of students completing the questionnaire on two occasions, yielding an ICC of 0.96. Subsequently, a descriptive cross-sectional study was conducted in 2022 to evaluate students' satisfaction with virtual education during the years 2020-2021. The target population consisted of medical students at Tabriz University of Medical Sciences who underwent their internship through virtual education during the pandemic. Data were collected from 197 medical students. Results indicated that 69.5% of students considered time-saving as the main advantage of virtual education. Results: issues such as poor internet quality (97%), reduced opportunities for clarification (79.7%), and lower engagement (66.5%) compared to in-person classes were reported. Additionally, 66% of students opposed conducting solely in-person classes and preferred a combination of virtual and in-person education.Item type: Item , Evaluation of depression anxiety, stress, and quality of life in people with Covid 19, six months after infection(Tabriz University of Medical Sciences, Faculty of Medicine, 2024) Motadaien, Fatemeh; Namvar, LeilaThe 2019 coronavirus disease (COVID-19) pandemic has severely affected the physical, mental, social, and spiritual health of the general population. Patients who have recovered and survived this disease are one of the affected groups. By January 2022, they will be more than 250 million people. However, observational studies reported that about 80% of these patients had some clinical manifestations that persisted several months after discharge or recovery from the infection. Considering the impact of this disease on the mental and physical aspects and finally the effects it has on the quality of life of these people, the purpose of this study is to investigate the state of depression, anxiety, stress and the quality of life of people with covid-19, six months later. It is important to identify the most important factors that disturb the quality of life by examining the results of the disease, and finally, to rehabilitate these people mentally and physically. Method: In this cross-sectional study after the approval of the Ethics Committee of the tabriz University of Medical Sciences, patients who were admitted to Imam Reza Hospital in Tabriz due to COVID-19 during the last six months were included in the study by following the inclusion and exclusion criteria. Questionnaire (BREF WHO QOL) and DASS were used to evaluate the quality of life and psychological disorders. Ninty two patients were selected, which were compared with 92 other healthy individuals by pre-designed checklists. Results: In this cross-sectional study, 130 patients were included in the study, which were two groups of case (65 people) and control (65 people). Among them, 67 people (51.5%) were men and 63 people (48.5%) were women. In the statistical analysis, there was a significant relationship between the intensity of depression, anxiety and stress of the two groups (P value < 0.05). In the statistical analysis, there was a significant difference between the physical health, mental health, social communication, environmental health and quality of life of the two groups (P value > 0.001). The strongest relationship was seen between stress and depression (p>0.01 and r=0.74), mental health and physical health (p>0.05, r=0.78) and depression and anxiety (p>0.01 and r=0.74). Binary logistic regression analysis showed that the level of education, depression, anxiety, stress, physical health, mental health, social relations, environmental health and quality of life as predictors for the presence of psychiatric symptoms in patients with COVID-19, 6 months after infections were identified. Also, in multivariate analysis, age between 31-60 years and environmental health were independent predictive factors for the development of mental problems after 6 months in patients with covid-19.Item type: Item , Investigating the survival rate and causes of the spread of rhinocerebral mucormycosis complications during three years of the covid-19 pandemic(Tabriz University of Medical Sciences, Faculty of Medicine, 2024) Bahari, Mahdi; Nouei Alamdari, ShabnamRhinocerebral mucormycosis is a rare but lethal fungal infection that primarily occurs in immunocompromised patients, particularly those with diabetes mellitus. These patients have been predisposed to mucormycosis due to the widespread use of corticosteroids for managing pulmonary inflammation in COVID-19 and inadequate blood sugar control. Unfortunately, at Imam Reza Hospital in Tabriz, we have witnessed a significant number of affected patients over the past three years, similar to treatment centers worldwide, leading to fatalities in young patients and cases of blindness. The timing of surgical interventions and complications during hospitalization has been emphasized. Given that Imam Reza Educational and Treatment Center was the primary facility admitting these patients, the aim of the present study is to evaluate the survival rates and the causes of complications associated with rhinocerebral mucormycosis during the three years of the COVID-19 pandemic. Materials and Methods: A cross-sectional study was conducted on 111 hospitalized patients diagnosed with probable mucormycosis during the three years of the COVID-19 pandemic at Imam Reza Hospital, confirmed by biopsy. For data collection, medical records of patients with a definitive diagnosis of mucormycosis stored in the hospital’s archive were reviewed. The study examined data such as the history of diabetes, prior COVID-19 infection within the last three months (based on positive PCR tests or clinical findings), history of immunocompromising conditions including cancers, organ transplant history, and recent high-dose corticosteroid use. The study assessed the relationship between the duration of symptoms, symptom severity, the interval between symptom onset and initiation of medical treatment, and the time between symptom onset and surgical intervention. Findings: In this study a significant relationship was observed between diabetes and blood sugar level, corticosteroid use and underlying disease with sever mucurmycosis complications and also the findings indicated that a time frame of less than 5-2 days from mucormycosis diagnosis to surgical intervention, and less than 24 hours from diagnosis to surgery, significantly contributes to preventing blindness and severe complications. Thus, there is an urgent need for prompt initiation of medical treatment and timely surgical intervention. Notably, three variables—visual impairment, the duration from mucormycosis onset to surgery, and the presence of necrosis—were identified as the most sensitive indicators of severe complications in these patients.Item type: Item , Study of Hepcidin Gene Polymorphisms in Patients with COVID-19-Associated Mucormycosis(Tabriz University of Medical Sciences, Faculty of Medicine, 2024) Farhand, Yalda; Ravanbakhsh Gavgani, Reyhaneh; Ravanbakhsh Gavgani, FatemehFollowing the coronavirus disease 2019 outbreak (COVID-19), it became a worrisome health burden worldwide. COVID-19-associated mucormycosis emergence, characterized by dysregulated inflammation and iron metabolism, exacerbated the prognosis of affected patients. Given the significance of هپسیدین in regulating inflammation and iron metabolism, this study investigated the significance of hepcidin single nucleotide polymorphisms (SNP) in COVID-19-associated mucormycosis development, along with the association between the clinical and laboratory factors and COVID-19-associated mucormycosis. Materials and methods: In this cross-sectional study, 110 patients with COVID-19 who had a history of hospitalization due to this disease in Sina and Imam Reza hospitals of Tabriz University of Medical Sciences in the summer of 1400 were included in the study. 50 patients had mucormycosis infection and 60 patients did not have it and were included in the study as a control group. Their medical records and laboratory results were reviewed. Peripheral blood samples taken from patients were transported to the laboratory in falcons containing EDTA. To extract DNA, first, the red blood cells of the blood samples were lysed using a lysis buffer solution until after centrifugation, a white sediment containing white blood cells was obtained. DNA extraction from white blood cells was done using the salting out method. Until the next steps, the DNA inside the 1.5 ml microtubes was transferred to a -20°C freezer and kept there. In order to investigate the nc-443C>T and nc-582A>G polymorphisms of the hepcidin gene, first the relevant specific primers were designed by GenRunner software and with the help of the NCBI website, and then by using the PCR technique and direct sequencing of the genotypes related to the polymorphism Hepcidin gene morphisms nc-443C>T and nc-582A>G were determined. SPSS version 25 software was used for data analysis. P<0.05 was considered statistically significant. Results: In this study, 110 COVID-19 patients with and without mucormycosis were examined. Increased serum levels of urea, aspartate aminotransferase, lactate dehydrogenase and increased ratio of polymorphonuclear neutrophils to lymphocytes were associated with a reduced risk of mucormycosis associated with COVID-19 in patients (all P < 0.05). Also, diabetes mellitus increased the risk of mucormycosis (P=0.028). None of the mucormycosis patients had SNP442 GA and SNP335 GT genotypes, and CC genotype and AA+CC genotype were associated with increased lactate dehydrogenase levels in COVID-19 patients, respectively.Item type: Item , Evaluating the relationship between circulating mitochondrial DNA in plasma and disease severity in patients with COVID-19(Tabriz University of Medical Sciences, Faculty of Medicine, 2024) Taghizadeh, Majid; Kazeminasab, Somayeh; Saghaleini, Hadi; Mahmoodpoor, Ata; Shadvar, KamranIn viral infections, mitochondria act as one of the main hubs of the pathogenesis. Recent findings present new insights into the potential role of circulating cell-free mitochondrial DNA (ccf-mtDNA) in COVID-19 pathogenesis by the induction of immune response and aggressive cytokine storm in SARS-CoV-2 infection. Objective In the presenting study, we hypothesized that having higher levels of ccf-mtDNA is associated with a poor prognosis in COVID-10. Methods The levels of ccf-mtDNA were investigated in 102 hospitalized patients with COVID-19 using the quantitative PCR (q-PCR) method. Results Statistical analysis confirmed a strong association between the levels of ccf-mtDNA and with mortality, ICU admission, and intubation. Also, our findings highlighted the pivotal role of comorbidities as a risk factor for COVID-19 mortality and severity.Item type: Item , بررسی ارتباط DNA میتوکندریایی در حال گردش در پلاسما با وخامت بیماری در مبتلایان به COVID-19(دانشگاه علوم پزشکی تبریز، دانشکده پزشکی, 1403) تقی زاده, مجید; کاظمی نسب, سمیه; ثقلینی, هادی; محمودپور, عطا; شادور, کامراندر اواخر سال 2019 میلادی ،بیماری COVID-19 با منشا SARS-COV-2 منجر به ایجاد پنومونی با همه گیری بی سابقه توام با مرگ و میر بالا گردید. این ویروس به طور بارز دستگاه تنفس را درگیر می کند . سن بالا و وجود بیماری های زمینه ای و دیگرعوامل با تاثیر بر پاسخ ایمنی بدن ، شدت و وخامت بیماری کرونا را تحت تاثیر قرار میدهند. تغییرات بین فردی می تواند ناهمگونی فنوتیپی پنومونی COVID-19 را توضیح دهد. مطالعات قبلی ،نقش مهم DNA میتوکندری، ساییدگی تلومر و نشانگرهای اپی ژنتیکی را، در کارایی سیستم ایمنی در بیماران با COVID-19 را مورد بحث قرار داده است. درمطالعه حاضر، ارتباط DNA میتوکندریایی در حال گردش در پلاسما با وخامت بیماری در بیماران COVID-19 مورد بررسی قرار گرفت. یافته های حاصل از مطالعه، ارتباط قوی بین تعداد رونویسی های ccf-mtDNA در مبتلایان به COVID-19 ، با میزان مرگ و میر، بستری در ICU و لوله گذاری داخل تراشه را نشان داد. روش کار و مواد: در مطالعه حاضر، با هدف بررسی ارتباط DNA میتوکندریایی در حال گردش در پلاسما با وخامت بیماری در بیماران COVID-19 ،پس از اخذ رضایت نامه کتبی از همراهان بیمار ، از میان افراد بستری شده در بخش مراقبت های ویژه بیمارستان امام رضا تبریز ، تعداد 102 بیمار وارد مطالعه گردید. DNA میتوکندریایی در حال گردش در پلاسما وقطعات میتوکندریایی مورد ارزیابی قرار گرفت. تجزیه و تحلیل نتایج با استفاده از نرم افزار SPSS نسخه 21 انجام شد. نتایج بر طبق نوع متغییر مورد بررسی بر حسب Mean ± SD و درصد بیان شد. Logistic regression آنالیز آماری برای بیان شدت بیماری COVID-19 و تغییرات میزان میتوکندری در حال گردش در پلاسما با لحاظ کردن تطبیق سنی و جنسی انجام شد. یافته های حاصل به صورت (OR) Odds ratioبا استفاده ازconfidence interval (CI) %95بیان شد. 5 0/0> P value معنی دار در نظر گرفته شد. یافتهها: تحلیل های آماری انجام شده ارتباط قوی بین تعداد رونویسی های ccf-mtDNA و میزان مرگ و میر، بستری در ICU و لوله گذاری داخل تراشه را تایید کرد، بطوریکه بالا بودن تعداد رونویسی ها در ارتباط مستقیم با افزایش موارد مرگ ومیر، افزایش نیاز به بستری در بخش های ویژه و افزایش موارد لوله گذاری داخل تراشه بود. همچنین، یافتههای بدست آمده نقش محوری بیماریهای همراه را به عنوان عامل خطری برای مرگ و میر و شدت COVID-19 نشان داد، با تعدد بیماریهای همراه ،شدت بیماری کووید و متعاقبا موارد مورتالیته و موربیدیتی به تناسب آن افزایش مییابد.