Investigating the Effect of Fenestration Surgery on Visual functions and Neurological Parameters in Patients with Idiopathic Intracranial Hypertension, A Retrospective Study

Abstract

Idiopathic intracranial hypertension (IIH) is a syndrome characterized by symptoms and signs of increased intracranial pressure without the presence of space-occupying or obstructive lesions. This study aims to evaluate visual and OCT parameters and to investigate the correlation between these parameters in IIH patients following ONSF surgery. Materials and Methods: This retrospective, non-comparative study was conducted on IIH patients who underwent ONSF surgery at Nikookari Eye Center, Tabriz, between 2020 and 2022. Pre- and post-surgery data, including demographic parameters, visual function tests (MD and VF), and optic nerve parameters through OCT, were collected and analyzed. Additionally, the correlation between OCT parameters was assessed and reported using Pearson's test. Results: The mean age of the patients was 35.57 years, with 90% being female. Post-surgery, significant reductions were observed in ONH, RIM area, Disc area, Macular GCL++, Macular GCL+, and Macular volume parameters (P<0.05). Furthermore, the mean C/D linear and C/D vertical values significantly increased at one month and three months post-surgery compared to pre-surgery (P<0.001). No significant changes were observed in the mean values of VF, MD, PSD, and Cup volume. Additionally, no significant correlation was found between Cup volume and Macular Volume at any time point (P>0.05); however, a significant correlation was observed between Total ONH and Rim area (P<0.001). VFI and Rim area were not significantly correlated pre-surgery (P=0.967) but demonstrated a direct and significant correlation post-surgery (P<0.001).