Evaluation of Cupressus Sempervirence crude extract on superficial basal cell carcinoma kinetics in patients referring to Sina hospital from 2020 to 2022

Abstract

Topical drugs are becoming increasingly popular in treating and recovering BCC. Herbal compounds are less harmful than chemical compounds due to natural substances. The plant C. sempervirens belongs to the Serosa family, whose anti-cancer compounds have been proven. Its effect on BCC recovery has been recorded in an animal model. This study aims to investigate the effect of cream-containing cypress plant extract on superficial basal cell carcinoma growth in patients referred to Sinai Hospital between 2020 and 2022. Materials and Methods: After collecting the young leaves of C. sempervirens from different regions, extracting the powder prepared from these leaves, and turning it into a topical cream, it was prescribed twice a day for at least six weeks for patients with superficial BCC who were confirmed by pathology and had visited the dermatology clinic between 2020 and 2022. Results: 14 patients with 32 superficial BCC lesions with an average age of 71 years were examined, of which nine were male. The most frequent location of BCC in patients was the forehead, followed by the scalp, chest, and abdomen. The most common complication observed in patients included mild erythema, which was observed in 6 out of 16 lesions. In terms of response rate to the treatment, among the 16 lesions under the intervention compared to the identical lesions of the control group, three lesions (18.75%) had almost disappeared (the leasions were cleared and in pathology there is no evidence of BCC), 1 case was related to back lesions, and 2 cases were related to abdominal and navel lesions. On the other hand, size reduction was observed in 3 lesions (18.75%), which were related to forehead and cheek lesions. Other lesions did not change in size, but no progress was observed during the follow-up period (stable clinical condition).