Preparation of an antiviral lip balm formulation based on extract from Alkanna orientalis (L.) Boiss
چکیده
Introduction: In the realm of lip health, one prevalent issue is the cold sore, caused by the Herpes Simplex Virus type 1 (HSV-1), leading to painful blisters known as cold sores. These lesions are a common concern in orofacial health due to their discomfort and visibility. Interestingly, traditional medicinal systems have long utilized herbal compounds like shikonin and alkannin, renowned for their antimicrobial and anti-inflammatory properties and effectiveness in wound healing. These natural secondary metabolites offering promising remedies for cold sores.Aims: Given the painful nature and distressing appearance of Herpes Simplex Virus (HSV) induced blisters, our research aimed to develop a cosmeceutical formulation with shikonin/alkannin derivatives as the active component. The application of this formulation is intended to speed up wound recovery and enhance the aesthetic appeal of the lips.Method: The initial phase of the study involved determining the optimal method for extracting shikonin and its derivatives from the powdered roots of Alkanna orientalis. Subsequently, a suitable lip balm base formulation was selected. The extract was then integrated as the principal ingredient and pigment into the lip balm formulation. Following the approval of the final formulation, stability tests were conducted, and various performance characteristics of the lip balm were assessed, also amount of active ingredient was measured using UV spectrophotometry after and before two months .Results: Shikonin derivatives were successfully extracted from the powdered roots of Alkanna orientalis. The extract was incorporated into a lip balm formulation, and the concentration of shikonin derivatives was quantified using UV spectrophotometry after and before two months. The lip balm formulation was optimized, and physicochemical and stability tests were conducted.Conclusion: Based on the results, shikonin derivatives can be successfully incorporated in the lip balm formulation.