Evaluation of the effects of dimethyl fumarate and celecoxib on vincristie induced neuropathy in mice

Abstract

Introduction: In the process of the formation of neuropathy caused by vincristine injection, several mechanisms have been proposed, including the activation of the oxidative stress system, increased activity of glutamate receptors, and increased activity of serotonin and inflammatory receptors. Dimethyl fumarate is effective in MS disease and has antioxidant effects. Seloxib is part of NSAIDS and has an antioxidant effect.Aim: The purpose of this study was to investigate the effect of dimethyl fumarate and celecoxib on neuropathic pain caused by vincristine in mice.Materials and methods: 81 male mice in the weight range of 25-35 grams were randomly divided into 9 groups of 9 and were subjected to treatment regimens for 18 days. Different doses of dimethyl fumarate (IP, 20, 40, 80 mg/kg) and celecoxib (10, 20, 40 mg/kg, ip) were injected three days before vincristine injection, and vincristine injection (IP, 0.1mg/kg ) was administered as a single daily dose for ten days. The animals were injected with the mentioned amounts of the studied drugs and the hot plate test was performed on the first day and on the last day of the study (18th day). Two days before the end of the study, seloxib and dimethyl fumarate injections were stopped.Results: The results indicated a significant increase (p < 0.05) in the reaction time to pain in animals at a dose of 20 mg/kg of dimethyl fumarate and different doses of celecoxib (10, 20, 40 mg/kg, ip).Conclusion: dimethyl fumarate (20 mg/kg, ip) and celecoxib (10, 20, 40 mg/kg, ip) can be effective in preventing neuropathy caused by vincristine. In order to obtain the exact mechanism of neuropathy prevention, we will need additional studies.