Comparison of the efficacy of spironolactone 5% solution with clindamycin 2% solution in patients with mild to moderate acne vulgaris in Tabriz

Abstract

Acne is a common disease in adolescence that can show itself as papules, pustules, and cysts in the face, chest, and back areas, and sometimes even continue until adulthood. Antibiotics are commonly prescribed in the treatment of acne both topically and systemically, and the results are often excellent. The aim of this study is to compare the effectiveness of 5% spironolactone solution with 2% clindamycin solution in patients with mild to moderate acne vulgaris in Tabriz. Methods: In a randomized clinical trial study, 60 patients with mild to moderate acne vulgaris were investigated in two groups (group A and B, 30 people each) and the therapeutic effects of 5% spironolactone and 2% topical clindamycin solution were compared. Both groups were followed up for 2 months. Results: In total, 19 patients (31%) were female and 41 patients (81%) were male. The average age of all investigated patients was 20 ± 4.3 years, and they were in the age range of 12-29 years. The difference in average TLC after treatment compared to before treatment in both groups was statistically significant (P<0.001). The results of the repeated measures analysis of variance test showed that the difference in the average ASI after treatment compared to before treatment was statistically significant in both groups (P<0.001).