The effect of surgical hemostat sponge containing aloe vera nanoparticles on the amount of pain and incidence of dry socket and comparing it with commercial geltamp after extraction of mandibular first and second molar teeth in patients referred to the surgery department of Tabriz Dental School

Abstract

Abstract Introduction: Hemostat sponges are new materials for rapid blood clotting, which are biocompatible and biodegradable, and can help blood clots at the site of surgery or tooth extraction and quick repair of the target site. The aim of the present study is to investigate the amount of pain and the occurrence of dry socket in a new hemostat sponge containing aloe vera nanoparticles after the extraction of the first and second molar teeth of the mandible (compared to the commercial geltamp in the market (Spongetan-Denmark)) in patients referred to the Tabriz Faculty of Dentistry. Materials and methods: A double-blind split-mouth clinical trial study was conducted on 30 patients referred to the surgery department of the Faculty of Dentistry in Tabriz with the indication of extraction of two mandibular molar teeth and meeting the inclusion and exclusion criteria of the study. In each patient, after tooth extraction, a gelatin sponge was randomly placed in the dental cavity for dressing, then a sterile gauze was placed on it (test group). And for the control group, a commercial foam gel was placed in the dental cavity for dressing, then a sterile gauze was placed on it. The conditions of tooth extraction, surgeon, equipment and surgical technique were the same for all patients. Pain was measured in the first 12 hours after tooth extraction and 24, 48 and 72 hours after tooth extraction. The pain level was measured using a visual analog scale (VAS) and the patient indicated his pain level at four points in time from 1 (lowest level of pain) to 10 (highest level of pain) by marking. Next, a special sheet for recording information after tooth extraction and providing necessary training on how to record was given to the patient, and the patient handed it in after completing the information. Also, the patients came for an examination 4 days later and were examined for the occurrence of dry socket. Data were analyzed by SPSS version 19 software and statistical tests. A probability value of less than 5 percent was considered as a significant level. Results: In both groups, average pain decreased significantly over time (P<0.05). Also, in each of the examined times, a significant difference in average pain was observed in the two groups (P<0.05), and the test group performed better. Also, no dry socket was observed in the patients. Conclusion: The performance of the new sponge containing aloe vera was better than the commercial geltamp in controlling pain after tooth extraction. In the case of dry sockett, both sponges had the same performance. Keywords: hemostatic effect, sponge, gelatin, aloe vera