The impact of COVID-induced autoantibodies in success rate of embryo implantation in patients with infertility

Abstract

So far, very few studies have investigated the effect of autoantibodies after the infection of covid-19 on the result of in vitro fertilization (IVF); And these reviews are much less about recurrent implantation failure (RIF). Autoantibodies with a proven role in RIF that are produced during covid can also have a negative effect on the result of IVF by changing their serum titer. In addition, other autoantibodies are also produced during covid, whose direct effect on the result of IVF, and especially RIF, has not yet been investigated. Therefore, we decided to investigate the effect of autoantibodies secondary to covid infection in people with RIF. Methods and Materials: In this observational study, blood samples were collected from 30 patients with frequent miscarriages referred to Valiasr Hospital in Tabriz. ELISA technique was used to measure autoantibodies. The studied autoantibodies included anti-nuclear (ANA), anti-phospholipid antibody, lupus anticoagulant, anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (anti-TG), anti-Annexin V, and anti-Beta2 glycoprotein. Results: The average age of the patients in the studied studies was 30.41 years, and their average body mass index was 27.11 kg/m2. In addition, the average duration of infertility of the patients was about 5.9 years and the number of previous attempts for embryo transfer was 3.7 times on average. The presence of autoantibodies against thyroid peroxidase, antiphospholipid antibody, and antinuclear antibody was more observed in patients with negative pregnancy and had a significant relationship with pregnancy success.