Correlation of Glycemic Control and COVID-19 Outcome in Diabetic Patients Admitted in ICU

Abstract

The disease of COVID-19 is especially in the elderly with type 2 diabetes with increased blood sugar levels, which puts these patients at risk of more severe infection and a poorer prognosis. The purpose of this study was to investigate the relationship between glycemic control in diabetic patients with COVID-19 hospitalized in ICU and disease outcome. Method: Patients with underlying diabetes disease who were admitted to Imam Reza Hospital in Tabriz due to the disease of COVID-19 between 2018 and 2019 were included in the study according to the BS level into two categories of moderate sugar control (BS between 140-180 mg/dl) and Severe (BS between 100-140 mg/dl) was divided and the characteristics of patients in two groups were compared. Results; The outcome of covid-19 patients with moderate blood sugar control was poorer compared to covid-19 patients with severe blood sugar control. The odds of both intrapartum and ICU mortality were 4.3 times higher for patients with COVID-19 whose blood glucose was moderately controlled (140 to 180 mg/dl) than for patients with severe hypoglycemia. (100 to 140 mg/dl) was controlled. Patients with strict glycemic control had less need for intubation and mechanical ventilation. Covid-19 patients with severe blood sugar control had lower levels of blood AST and LDH, which may be in favor of the lower severity of liver and lung involvement in these patients, respectively, compared to Covid-19 patients with moderate blood sugar control. No significant difference was observed in terms of age and sex, as well as weight and BMI between the patients of the two groups.