Evaluation of effective factors in the incidence of liver fibrosis in diabetic patients

Abstract

In patients with type 2 diabetes, it has been shown that liver fibrosis increases with the progression of diabetes. However, data on the extent of liver fibrosis in patients with diabetes and factors predicting progression to liver fibrosis are scarce. This study will be conducted in order to determine the level of liver fibrosis and related parameters predicting liver fibrosis in these patients, including HBA1C. If there is a relationship between the level of HBA1C and elastography findings in diabetic people, it can be done by evaluating the level of HBA1C, which is a cheap and accessible method. Diabetic patients exposed to non-alcoholic fatty liver can be identified more quickly and introduced to elastography for screening in terms of fatty liver and predicting the risk of developing fatty liver. With this method, fatty liver, which currently has a very high prevalence in diabetic patients, can be identified as quickly as possible and from Prevented progression to chronic liver failure; Therefore, the aim of the present study was to investigate the effective factors in the occurrence of liver fibrosis in diabetic patients. Materials and Methods: This study was a cross-sectional analytical study. In this study, diabetic patients referred to the endocrinology and general clinics of Imam Rezai Hospital in Tabriz in 2001 were included in the study. 5 cc of blood was taken from the patients, which was sent to the laboratory for biochemical tests, blood cell count (CBC), liver and lipid tests, and HBA1c. Also, demographic variables including age, sex, year of diabetes, history of drug treatment, and history of previous diseases were recorded. Patients were then subjected to elastography by a gastroenterology specialist in the endoscopy department of Imam Reza Hospital, and the correlation of elastography findings with HBA1c level, fasting sugar level, BMI, and LDL was investigated. Results: The range of HbA1C factor in diabetic patients with fibrosis was 12.5 to 8 with an average of 7.70 and in diabetic patients without fibrosis, it was 8.5 to 8 with an average of 6.81. Statistically significant difference in terms of HbA1C was observed between two groups of patients with fibrosis and patients without fibrosis, so that the average of this factor was higher in diabetic patients with fibrosis than in patients without fibrosis. Also, the average level of HbA1C factor in diabetic patients with fibrosis was higher than the normal level (P = 0.036); High levels of HbA1C in people with liver fibrosis were significantly higher than people without liver fibrosis (P=041).