Prognostic value of CRP to Albumin ratio in Acute Coronary Syndrome: a systematic review and meta-analysis

Abstract

Acute coronary syndrome (ACS), which refers to a set of clinical presentations, is the most important cause of death from heart disease. More recent studies have investigated the prognostic value of C-Reactive Protein to albumin ratio (CAR) in ACS patients. However, no systematic review has summarized the results of these studies. Therefore, this systematic review and meta-analysis was conducted with the aim of investigating the prognostic value of CRP/Alb in patients with ACS. Methods: Using appropriate keywords, relevant studies published in English from the beginning to June 30, 2024 were searched from EMBASE, Web of Knowledge, PubMed, Scopus, Google Scholar. After screening the studies, the required information was extracted from the final included studies and a meta-analysis of the data related to mortality and major cardiovascular events (MACE) was performed using STATA version 17.0 software. Results: 11 articles were included in this meta-analysis study, so that 4 studies in the meta-analysis related to mortality and 7 studies in the meta-analysis related to MACE were examined. The results of the meta-analysis of CAR and mortality indicate a significant higher incidence of death in people with ACS with a higher CAR ratio. (OR=1.18, 95% CI 0.99-1.37, p˂0.001). The results of the meta-analysis of CAR and MACE also indicate a significant higher occurrence of MACE in people with ACS with a higher CAR ratio. (OR=1.74, 95% CI 1.09-2.40, p˂0.001).