The effect of herbal mixture extract on endometrial histology in patients with disordered proliferative endometrium and simple hyperplasia

Abstract

Endometrial hyperplasia is a non-physiological and non-invasive proliferation of the endometrium that can lead to endometrial cancer. The lack of standard and non-invasive treatment options highlights the need for new treatments. In recent years, many clinical trials have been conducted regarding the use of medicinal plants in the treatment of endometrial hyperplasia, and there is a need for further evaluation of the effectiveness of this method. Method: In this clinical trial, 80 patients who referred to the oncology department of Al-Zahra Medical Education Center in Tabriz with complaints of menorrhagia and were diagnosed with proliferative endometrium with irregular glands or simple hyperplasia by diagnostic curettage or endometrial biopsy were included in the study. They will be randomly divided into 2 intervention and control groups. Patients in the control group received cyclic megestrol acetate 40 mg, and in the intervention group, patients received cyclic megestrol acetate 40 mg along with a combination of 500 mg herbal extract, which includes 300 mg turmeric extract, 80 mg lemon balm extract, 100 mg, orange peel and 20 mg of chasteberry extract daily for three months. Endometrial tissue was compared in two groups after three months. Results: Out of a total of 80 patients who were initially included in the study, a total of 73 patients were included in the final analysis. There was no significant difference between the intervention group and the control group in anthropometric variables, the history of taking contraceptives, the presence of concomitant diseases, and the history of childbirth and pregnancy of the patients. In the intervention group, 83.3% (30/36) of the patients and in the control group, 62.2% (23/37) of the patients responded to the treatment, and this difference between the two groups was statistically significant. Also, in both groups, one case of disease progression to atypical hyperplasia was recorded.