Correlation of sepsis induced coagulopathy score with covid-19 out come, severty and mortality

Abstract

The COVID-19 pandemic has become an urgent issue worldwide. Given the limited healthcare infrastructure, it is crucial to prioritize the hospitalization of patients with more severe disease. Recent reports indicate that the most severe COVID-19 cases often involve blood clotting abnormalities, suggesting that clotting tests may be useful for diagnosing severe cases and prioritizing treatment. In this retrospective descriptive study, we examined the association between Sepsis-Induced Coagulopathy (SIC) scores and the severity, prognosis, and mortality of COVID-19 patients. Method: Eighty patients with COVID-19 were included in the study from 1/1/1399 to 29/12/1400, based on the results in their medical records. Demographic data, mortality before discharge, length of hospital stay, vital signs at admission, and biochemical data were recorded. For each patient, the SIC score was calculated according to the relevant guidelines. The relationship between SIC scores and disease severity, prognosis, COVID-19 mortality, and other recorded variables was then examined. Results: Our results showed that inpatient mortality was significantly associated with older age (P=0.001), higher white blood cell counts (P=0.008), prolonged Prothrombin Time (PT) (P=0.001), elevated International Normalized Ratio (INR) (P=0.001), higher creatinine levels (P=0.001), and lower blood oxygen saturation levels (P=0.001) and Glasgow Coma Scale (GCS) scores (P=0.001) compared to the mortality-free group. The total Sequential Organ Failure Assessment (SOFA) score was significantly higher in patients who died in the hospital (P=0.001). Similarly, the SIC score was higher in the mortality group, primarily due to differences in INR between the groups (P=0.049). No link was found between the length of hospitalization and SIC scores in hospitalized COVID-19 patients.