Investigating the correlation between serum concentration of autophagy 5, apolipoprotein B48, thyroid hormones and homocysteine in patients with Alzheimer's disease

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with cognitive impairments and the most common cause of dementia, characterized by progressive loss of short-term memory and loss of mental abilities of the affected person. Sedimentation of two proteins called amyloid beta and tao protein in brain tissue is one of the most important cognitive findings of Alzheimer's disease. One of the most important challenges of this disease is early diagnosis. Studies have shown that factors such as diabetes, hypertension and fatty diet, thyroid hormones, homocysteine neurotoxicity, carotid artery contraction, atherosclerosis complications, decreased autophagy protein expression and increased lipid class have a role in the incidence and progression of this disease.

Material and Method

This cross-sectional study was a cross-sectional study, 50 patients in the early stages of the disease and 50 healthy individuals were selected as the case and control groups, respectively. Blood clot samples (serum isolation) were taken to measure different parameters of the study, then serum concentrations of apolipoprotein B48, autophagy protein 5, homocysteine and thyroid hormones were measured by ELISA method and lipid profiles were measured by autoanalysis and staining method. The obtained data were evaluated by statistical software.