The relation between atherogenic index of plasma and liver enzymes in Azar cohort population

Abstract

Atherogenic index of plasma is a logarithmic ratio of TG to HDL. This index is a strong tool for estimating the risk of diseases such as cardiovascular diseases and NAFLD. Its normal level is reported to be 0.11-0.21. This index is affected by factors such as age, sex, lifestyle and underlying diseases. In recent years, the relationship between AIP and liver enzymes has received more attention, and this relationship can be used to predict the occurrence of diseases. This study was conducted with the aim of investigating the relationship between AIP and liver enzymes.

Method : At the beginning of this study, there were 15,006 participants, which were reduced to 14,720 participants based on the Azar cohort questionnaire and exclusion criteria. Demographic and anthropometric information of the participants, lipid profile levels (triglycerides, cholesterol, HDL, LDL) and liver enzymes (AST , ALT, ALP, GGT) were measured. Using rank regression, the atherogenic index of plasma was evaluated as an independent variable and liver enzymes as a dependent variable, and age, sex, body mass index, physical activity and economic status, amount of consumption Alcohol, smoking and fatty liver disease were modified as confounding factors.

Results: After examining the collected data, it was found that the level of AIP is directly related to the level of all liver enzymes, and all enzymes are not related to AIP to the same degree, and GGT is the most related. On the other hand, old age, male gender, alcohol consumption and Smoking can cause an increase in AIP followed by an increase in liver enzymes. All these changes were significant and the p-value for all changes was less than 0.05.