Determining and compairing of the prevalence and severity of respiratory distress syndrome in preterm infants with gestational age less than 34 weeks born to mothers with and without Covid 19 hospitalized in Al-Zahra Hospital, Tabriz, from April 2020 to september 2021

Abstract

Respiratory distress syndrome in newborns (hyaline membrane disease) is a respiratory disease, mainly in premature babies with a gestational age of less than 28 weeks (60-80%) and babies with a gestational age of 32-36 weeks (15-30%), but in Babies over 37 weeks are rarely seen. Its important differential diagnosis is sepsis with early onset, pneumonia, cyanotic heart diseases, persistent pulmonary hypertension, aspiration syndromes, transient tachypnea, and finally, COVID disease. -19, which causes pulmonary involvement in infants born to infected mothers. Distinguishing between pulmonary symptoms of COVID-19 and respiratory distress syndrome and sepsis is currently a challenge. The purpose of this study is to investigate the frequency and severity of respiratory distress syndrome in premature infants under 34 weeks born to mothers infected with COVID-19 and to compare its results with the findings of infants with similar conditions born to mothers not infected with COVID-19. Methods: In this study, all premature babies under 34 weeks hospitalized in Al-Zahra Hospital in Tabriz from the beginning of April 2019 to September 2014 were selected and divided into two groups according to whether or not the mother was infected with COVID-19. The first group of infants born to mothers infected with COVID 19 is called the case group and the second group, infants born to mothers not infected with COVID 19, is called the control group, and both groups were investigated and monitored in terms of the incidence and severity of respiratory distress syndrome. . Finally, the clinical and paraclinical results and findings in both groups were analyzed using SPSS 22 statistical software and analytical statistical tests. Results: In the two studied groups (infants born to mothers with and without covid), the investigated variables, including weight, sex, gestational age, receiving corticosteroids before birth, maternal diseases, the type and duration of respiratory support of the newborns, the need for Auxiliary oxygen, mortality rate, length of hospital stay, RDS SCORE, and some laboratory indexes (CBC, PLATELETE, LFT) had no significant difference. At the same time, the need for resuscitation after birth, the severity of clinical and respiratory symptoms, the amount of antibiotics received, and the levels of CRP and LDH in the case group (babies born to mothers with covid) were significantly higher than the control group (babies born to non-covid mothers). ).