Effects of vitamin D with and without vitamin B6 in the prevention of carpal tunnel syndrome in women undergoing breast radiotherapy

Abstract

Getting breast cancer and receiving therapeutic drugs in women, along with the treatment of this disease, leads to the occurrence of many complications and disorders, among which we can mention the reduction of micronutrition. Also, there is a two-way relationship between cancer and micronutrients such as vitamins, so that both cancer leads to a decrease in the levels of these vitamins, and the decrease in these vitamins also contributes to the occurrence of cancer; According to the mentioned materials, the aim of this study was the effects of vitamin D with and without vitamin B6 in preventing carpal tunnel syndrome in women undergoing breast radiotherapy. Methods: 120 patients were divided into three groups of 40 people using a random number table. Patients entered the study and received the intervention before breast radiotherapy. The patients in the vitamin D group received 200 units of this medicine orally (taken every night with a glass of water) and for the patients in the vitamin D + vitamin B6 group, in addition to taking a 200 unit pill of vitamin D daily, They also received a 200 mg vitamin B6 tablet orally (both drugs will be taken at night with a glass of water). No drugs were prescribed for the patients of the control group. The duration of treatment for all patients was three months. At the end of each month, the patients were evaluated for carpal tunnel syndrome and pain intensity in the hand area, and their results were compared with each other. Results: Fallen's test, comparison test and pain intensity in patients of vitamin D±B6 group had a better condition than the other two groups at all times; Also, the use of vitamin D±B6 in patients who are candidates for breast radiotherapy leads to the occurrence of mild symptoms of carpal tunnel syndrome, while the non-prescription of these vitamins in the control group led to moderate symptoms of carpal tunnel syndrome after three months of breast radiotherapy.