Prospective study of the correlation between survivin level and disease activity in Lupus patients

Abstract

Lupus is a chronic autoimmune disease in which T and B lymphocytes can involve different organs such as skin, kidney, nervous system, etc. Survivin is a protein from the apoptosis inhibitor family, which in recent years due to its anti-inflammatory effect Apoptosis, as well as the effect on cell growth and involvement in the pathogenesis of some autoimmune diseases, such as rheumatoid arthritis, myasthenia gravis, psoriasis, lupus, etc., have been considered. Nephritis is a prospective study. Methods: At the beginning of the work, after the patients entered the study, the data collection form of patients with lupus was completed, and in the next step, blood was drawn and centrifuged to separate mononuclear cells from peripheral blood and plasma. This work was done in four stages with a time interval of 3 months on the group of patients for a period of one year. In the selection of patients, the condition of the patient, their place of residence and the possibility of their follow-up were taken into consideration. Demographic information and clinical information of the patient were collected in order to investigate the impact of environmental factors and the presence of other background diseases interfering in the study process. Findings: In the studies, no statistically significant difference was found between the sex and age of the control group and patients, which indicates the lack of difference in this information and the reduction of bios of the effect of age and gender in our study. In the study of 24-hour urine protein variables , serum creatinine and SLEDAI, no statistically significant difference was seen in the visits in the three visits compared to each other. Comparing the control group with the patient group in terms of survival level in all three visits in the patient group, the survival level in the patient group was significantly compared to the group It is higher. The level of survivin in the group with lupus can be seen compared to the control group, which was also statistically significant.