Determining the relationship between the serum level of liver enzymes and demographic factors in the studied population in East Azarbaijan province in 2018

Abstract

Background and purpose: Hepatic enzymes such as alanine and aspartate aminotransferase (ALT and AST) are released into the blood circulation following liver cell damage. Considering the possibility of the effect of demographic variables on the level of these enzymes, this study was conducted with the aim of investigating the serum level of liver enzymes and its relationship with demographic indicators in the population of East Azarbaijan province in 2017. Methodology: This design is a retrospective cross-sectional study. In the mentioned study, the demographic information collected from 1500 households living in Tabriz city and several cities of this province (150 clusters of 10 households) which were in similar groups in terms of socio-economic variables, distance from the center, population and access to health care facilities, were analyzed. . The information obtained from measuring the level of these enzymes as well as anthropometric indices were examined. ALT levels higher than45 U/L in men and 34U/L in women and AST levels higher than 35U/L in men and 31U/L in women were considered abnormal. In the end, the data was analyzed by SPSS V18. Findings: 2816 people were examined in the present study. The age group of 45 to 55 years was the largest age group in the population. 41.2% of the studied population were male and 87.3% were married. In total, the prevalence of high ALT level in the studied population was 4.1% and for AST was 4.7%, and the highest prevalence of high liver enzymes is between the ages of 35 and 55 years. The prevalence of high level of ALT in Tabriz city was significantly higher than other cities, but there was no significant difference between the capital of the province and other cities in terms of the prevalence of high level of AST. Conclusion: The results show that gender has no effect on the high level of liver enzymes in the studied population. On the other hand, considering that high levels of liver enzymes are more common in the population aged 35-55 years, more studies are necessary in terms of investigating related causes, including lifestyle and co-morbidities.