Design and construction of a temperature and humidity control device in the respiratory tract and lungs in an animal model

Abstract

Abstract: The respiratory system is a biological system whose task is to supply oxygen to body cells and remove carbon dioxide (carbon dioxide) resulting from metabolism. Every year, lung diseases affect many people in the society, which reduce the level of performance of a person in daily activities. About 65 million people suffer from chronic obstructive pulmonary disease (COPD) and 3 million people die from it each year, making it the third leading cause of death worldwide. We tried to design and build a device that inactivates or destroys respiratory viruses by applying temperature and humidity. The device controls the temperature based on the built-in furnace and also the temperature sensor and directs it to the lungs through the ducts and the built-in mask. This device was used in an animal study on 9 male rats with an average weight of 202 grams in a temperature range of 41 to 50 degrees Celsius to investigate the tolerance threshold of the lungs. The lungs of the rats were cut in different ways and analyzed. In this study, we demonstrated that delivery of heated humidified air at 39°C and 42°C was well tolerated by healthy rats for 5 minutes. 8 rats out of 9 animals were examined if they were to receive nasal hyperflow therapy for cold and/or flu symptoms according to the experimental protocol. None of our rats reacted to stop high blood flow treatment in this study. We have also shown that high nasal flow treatment at 35 L/min is well tolerated by healthy animals, and increasing temperature from 37°C to 41°C does not affect tolerability.