The Effect of Edaravone on the Oxidant/Antioxidant System of the Heart After Renal Ischemia-Reperfusion Injury in an Animal Model

Abstract

Acute ischemic kidney injury (AKI) can lead to the occurrence of oxidative stress in distant organs, such as the heart tissue. In the context of cardiovascular diseases, Edaravone has been found to effectively scavenge free radicals. The objective of this study was to investigate the antioxidative effects of Edaravone specifically on the heart tissue following the induction of renal ischemia-reperfusion injury (IRI). Method A total of 24 male Wistar rats were included in this study. The rats were randomly divided into the sham, ischemia/reperfusion, Edaravone, and ischemia/reperfusion + Edaravone (n=6 in each). Non-traumatic clamps were used to stop the artery and vein blood flow of the left kidney in rats of the IR groups for 45 minutes. 100 mg/kg of Edaravone was administered intravenously 30 min before the induction of ischemia. Cardiac tissue samples were subjected to biochemical analyses. Results Our results showed that SOD, TAC, GSH, and GPx levels of the IR+ Edaravone group were significantly increased compared to the IR group (p≤0.05). Moreover, SOD, TAC, and GSH levels of the Edaravone group were increased in the Edaravone group compared to the IR group (p≤0.05).