Comparison of the effect of combining midazolam with dexmedetomedine and propofol with dexmedetomedine to enhance the medical hemodynamic status of a colonoscopy candidate

Abstract

ince most of the people who refer for colonoscopy are over 50 years old and at this age people's reaction to various drugs such as midazolam and propofol show their condition in the form of severe changes, the use of sedative drugs should be It should be used with extreme caution and in the lowest available dosage, so that in addition to the effects of analgesia, sleep, and anti-anxiety that these drugs have, we can measure the effects of these drugs on the changes in hemodynamic status by using less drug and adding dexmedetomidine to these drugs. According to the mentioned materials, the purpose of this study is to compare the effects of the combination of midazolam with dexmedetomidine and propofol with dexmedetomidine on the changes in the hemodynamic status of colonoscopy candidates. Methods: This study is a randomized and double-blind clinical trial study that was conducted in Imam Reza Hospital of Tabriz University of Medical Sciences with the participation of 80 patients. Patients will be included in the study by observing the entry and exit criteria; The patients received the medicine 3 minutes before the gastroenterologist started working. Group M patients: For these patients, half the dose of midazolam along with 25 micrograms of dexmedetomidine will be prescribed, followed by the hemodynamic status in the first ten minutes once every minute and then once every 5 minutes until the end of the colonoscopy. will be measured. Group P patients: For these patients, half the dose of propofol along with 25 micrograms of dexmedetomidine will be prescribed, followed by the hemodynamic status in the first ten minutes once every minute and then once every 5 minutes until the end of the colonoscopy. Results: The results indicated that heart rate, systolic blood pressure, and diastolic blood pressure during the first ten minutes in the propofol + dexmedetomidine group patients were significantly more unstable than the midazolam + dexmedetomidine group patients; Also, the changes in hemodynamic status during the whole period of colonoscopy in the patients of the propofol + dexmedetomidine group were more unstable than the patients of the midazolam + dexmedetomidine group. Instead, the intensity of pain, the amount of injected fentanyl and propofol in the propofol + dexmedetomidine group patients was significantly lower than the midazolam + dexmedetomidine group patients. The incidence of recovery complications was significantly higher in the patients of the propofol + dexmedetomidine group than in the patients of the midazolam + dexmedetomidine group.