Thermodynamic study of deferiprone dissolution in the binary system of 2-propanol and polyethylene glycol 400

Abstract

Solubility data have many industrial applications and the change in solubility is used in dissolution, formulation and crystallization processes. There are various techniques to change the solubility of drugs, including cosolvency, particle size reduction, crystal engineering, salt formation, solid dispersion, surfactant use, and complex formation. Cosolvency is one of the simplest and best methods.Aim: Our aim is to investigate the thermodynamic solubility of deferiprone in PEG400 and 2-propanol solvent system and to predict the solubility data with cosolvency models.Method In this research, the shake-flask method was used to measure the solubility of deferiprone in PEG400 and 2-propanol solvent system. In this method, the excess amount of medicine is dispensed into containers with different mass ratios of cosolvent + solvent (11 fractions). After reaching the equilibrium of the solution at the set temperature, the supernatant solution is separated from the remaining solid material by centrifuge or filter, and after proper dilution, the absorbance is read by the UV-Vis spectrophotometer at λmax of the drug and the concentration is reported referring to drug calibration curve.This process has been repeated at 5 different temperatures and then using the cosolvency models the amount of drug solubility has been predicted and finally experimental data and predicted data have been compared and correlated.Results:Based on experimental data, we find the solubility of deferiprone increases with the increase in the mass fraction of PEG400 and temperature. So that the highest solubility of deferiprone is observed for naet PEG400 at 313.2K. Also the lowest solubility of deferiprone was reported for neat 2-propanol at 293.2K. Conclusion:The solubility of deferiprone increased with the increase in temperature and the mass fraction of PEG400. Also, the experimental data were correlated with the data of different cosolvency models and good results were obtained from data modeling.