Investigating the effectiveness of Iranian traditional medicine products (honey and grapes) on improving the sensory symptoms of peripheral neuropathy in an animal model

Abstract

Introduction: Several mechanisms, including increased activity of the glutaminergic system (NMAD receptors), production of free radicals and intensification of the oxidative stress system, are involved in cisplatin-induced neuropathy. Ceftriaxone as an antibiotic reduces the function of the glutaminergic system. Honey and grape juice also have antioxidant effects.The aim of this study was to compare the effect of Iranian traditional medicine products (honey and grapes) on the improvement of sensory symptoms of peripheral neuropathy in male mice. Materials and methods: 56 male mice weighing 25-35 grams were randomly divided into 7 groups (n= 8). One week before cisplatin injection, honey (10ml/kg, p.o.) and grape juice (10 ml/kg, p.o.) and a combined dose (honey + grape juice) were prescribed. The tail flick test was used to evaluate the effect of different diets on increasing pain sensitivity. At the end, the serum level of MDA and TAC was evaluated. Results: The delay time in the group consuming grape juice, the group consuming honey, as well as the group consuming honey and grape juice at the same time, and the groups receiving pregabalin and ceftriaxone increased significantly (P<0.05). The serum level of TAC increased significantly in the group receiving grape juice and the group consuming honey (P<0.5). The serum level of the MDA biomarker decreased significantly in the group consuming honey and the group consuming honey and grape juice at the same time (P<0.05). Conclusion: Consumption a regime containing grape juice, honey or both of these substances can increase the pain threshold by increasing the delay time and have a protective effect in neuropathy.