Comparison of the effects of ondansetron, dexmedetomidine, ketamine and meperidine in the prevention of nausea and vomiting, pain and chills after knee arthroplasty under spinal anesthesia: a randomized clinical trial

Abstract

The effects of ondansetron, dexmedetomidine, ketamine and meperidine in the prevention of chills, pain, nausea and vomiting have been studied in various studies; Since each of these drugs acts with a different mechanism than the other drugs, we intend to compare these four drugs in terms of their preventive power. On the other hand, due to the fact that knee arthroplasty is one of the surgeries with a relatively high incidence of nausea and vomiting and chills and pain after surgery, the present study aimed to compare the effects of ondansetron, dexmedetomidine, ketamine and meperidine in preventing nausea and vomiting. Shivering will occur after knee arthroplasty. Materials and Methods:200 patients with knee arthroplasty were included in this study by available sampling method and after random assignment in four groups, received the relevant intervention. The ondansetron group found 4 mg, the pethidine group 0.5 mg/kg, the ketamine group 0.5 mg/kg and the dexmedetomidine group 1 micg/kg body weight. The drugs were injected intravenously half an hour before the start of anesthesia. The rate of nausea, vomiting, pain and chills after surgery were compared between the four groups and will be compared with descriptive and inferential statistical tests. Pi level less than 0.05 was considered significant. Results:The results of the present study showed that the prophylactic effects of dexmedetomidine in controlling chills and pain were significantly better than meperidine, ketamine and ondansetron; While ondansetron had better effects to prevent nausea and vomiting; However, no significant differences were observed between prescription drugs for the control of nausea and vomiting.