Effects of Probiotic on IL6 and TNF-a levels on patients with nonalcoholic fatty liver disease

Abstract

Recent studies emphasize the relationship between IL6-TNF levels and the severity of liver damage, and higher levels of IL6 and TNF are associated with the severity of liver damage. According to recent studies, the effect of inflammatory cytokines in the pathogenesis of non-alcoholic fatty liver disease patients and the limited interventional studies on The level of cytokines in the treatment of non-alcoholic fatty liver disease and the need to provide effective treatments for this disease and considering the widespread prevalence of obesity and its complications that can progress to liver failure and hepatocellular carcinoma and considering the low effect of nutritional and behavioral modification methods Based on weight loss and the lack of specific treatment for NAFLD, we decided to investigate the effect of probiotic medicine on the level of inflammatory cytokines in the treatment of patients with non-alcoholic fatty liver disease. Materials and Methods: The present study is a double-blind randomized clinical trial. In order to conduct this study, patients with non-alcoholic fatty liver diagnosed by ultrasound findings were intervened. Then the patients were randomly divided into two control and intervention groups. In the first group, in addition to their usual treatments, they received probiotic tablets for 3 months, and the control group also received a drug with a similar appearance as a placebo in addition to their usual treatments. The levels of IL6 and TNF before and after the end of the intervention were measured and compared between the two groups. Results: Intragroup comparison of biochemical indices indicated that triglyceride (P=0.014) and (P=0.001) LDL and cholesterol levels (P=0.001) and (P=0.014) ALT and AST (P=0.009) and interleukin 6 (P=0.032) and TNF (P=0.014) were significantly associated with a decrease in the intervention group; Also, the inter-group results indicated that the levels of (P=0.014) LDL triglyceride (P=0.048) and cholesterol (P=0.03) and (P=0.001) ALT and (0.039) AST, TNF (P=0.025) and interleukin 6 (P=0.006) were significantly lower in the intervention group than in the control group