Systematic review of therapeutic effectiveness of oral supplements on patients with Duchenne muscular dystrophies

Abstract

Duchenne Muscular Dystrophy (DMD) is the most common form of muscular dystrophy in childhood, caused by deletion in the DMD gene. It often causes progressive weakness starting in childhood and become wheelchairs bounde. Premature deaths occur in the early twenties due to cardiovascular problems. Prednisolone treatment in these patients is associated with complications such as weight gain, cushingoid appearance, hirsutism, glucose intolerance, and delayed puberty cataracts. In this study, the effect of oral supplements in people with Duchenne dystrophic disease was evaluated, so that the results of the systematic review of these studies can be used for other patients. Materials and Methods: After extracting from the target databases, the keywords were evaluated by two evaluators using the CONSORT evaluation checklist for various types of bias risks. Studies were evaluated using the article quality assessment checklist (CONSORT) and based on the agreement of two independent evaluators of article quality in accordance with existing standards in terms of types of bias risks including (selection, performance, identification, attrition, reports). After careful study and extraction of required information, the extracted results were first summarized by a pre-designed Extraction table in EXCEL software environment and the data required for meta-analysis entered into CMA software were analyzed. Data were analyzed by CMA (Comprehensive Meta-Analysis) software. Results: After the selection process was described using inclusion and exclusion criteria, 9 studies were eligible to be included in our systematic review. These 9 studies included 6 randomized double-blind randomized clinical trial studies. The other three studies were open-label, single-center, non-randomized pilot studies in the cohort study category. Supplements studied in this study: Omega 3 (2 articles), L-Citrulline (1 article), Calcium and vitamin D (2 articles), Creatine monohydrate (2 articles), Selenium and Vitamin E (1 article), glutamine and amino acid (A total of 252 boys were examined in these articles. Due to the dispersion between dietary supplements and response criteria, there was a statistically significant relationship between the total data, both in terms of type of oral supplement and type of response to treatment. There was nothing between them.