Evaluation of the relationship between HbA1c and blood glucose measurements during surgery in diabetic and non- diabetic patients

Abstract

Several studies have demonstrated role of glycosylated hemoglobin in prediction of postoperative complications in patients undergo surgery, therefore we aimed to evaluate correlation between preoperative HbA1C and intraoperative blood glucose levels change in diabetic and non-diabetic surgery patients. Materials and methods: In current prospective analytical study, 290 patients, candidate to undergo orthopedic surgeries enrolled study. Prior to anesthesia, venous blood sample collected to measure HbA1C and blood glucose level. Intravenous line administrated for repeated collection of blood samples to evaluate blood glucose level, which performed by a single laboratory. Anesthesia administered in all patients using a single protocol. Results: In current study, of 290 patients, 94 patients (32.4%) were female and 196 patients (67.6%) were male, however, there were no significant difference between diabetic and non-diabetic patients in terms of demographic variables. Mean levels of HbA1C in diabetic patients were significantly higher than non-diabetic patients (P< 0.0001). Using Mixed model, analysis showed more severe changes in levels of intraoperative and postoperative blood sugar levels and higher incidence of hyperglycemia in patients with diabetes. In addition, linear regression provided a significant correlation between increased HbA1C level and higher blood sugar with postoperative hyperglycemia (P< 0.0001, P: 0.013).