Efficacy of Furosemide 0.125 % topical gel and KOH 10% topical solution in treatment of patients with warts: a comparison study

Abstract

Wart is a common skin disease all over the world and it is more common in childhood, but it can be seen in any age group. According to cohort studies, 5 to 30% of children and adolescents are affected by this skin disease. Furosemide drug has been used topically to reduce the size and prevent the recurrence of polyposis of the nose and sinuses after endoscopic surgeries. According to these studies, no specific side effects have been reported following the use of this drug. The current study aims to compare the effectiveness of Furosemide 0.125% topical gel and KOH 10% topical gel in the treatment of patients with warts. Materials and Methods: In this clinical trial, patients referred to the clinic with warts were included in the study voluntarily and after obtaining written consent according to the inclusion criteria. Patients were diagnosed clinically by dermatologists. Some of the patients were treated with 0.125% furosemide and some with 10% KOH. The duration of the study was two months and the patient used both drugs once a day. At the beginning of the study and in weeks 4 and 8, patients were examined and imaged in terms of the number, diameter, and height of warts and the occurrence of unwanted complications. Results: 40 patients (48 lesions) with common warts were studied in two intervention groups of 10% KOH and 0.125% furosemide. In the KOH and furosemide group, the average wart diameter in the first visit was 3.89 ± 1.67 mm and 4.25 ± 1.43 mm, and 3.02 ± 1.49 mm and 4.14 ±1.47 mm in the final visit, respectively. No complications were observed in the furosemide group, while in the KOH group, 7 complications related to redness and burning were observed.