Evaluatin of Predicting value of troponin for mortality in patients with covid 19

Abstract

The clinical significance of cardiac troponin measurement in patients hospitalised for coronavirus disease 2019 (covid-19) is uncertain. In this study, we investigated the prediction of troponin in the mortality of patients with COVID 19. Materials and Methods: In this study, all patients with a definite diagnosis of covid-19 referred to Imam Reza Tabriz emergency room during the first 9 months of 2020 (4096 people) were included in the study. The definitive diagnosis of covid was based on the sum of the patient's complaint, hematological and biochemical tests, and the result of PCR and chest CT. Results: Out of a total of 4096 patients, 2255 patients (54.1%) were male and 1841 patients (44.9%) were female with an average age of 60.2 ± 16.7 years, the lowest being 16 years and the highest being 94 years. The most common severity of respiratory symptoms was shortness of breath in 59.8%, cough in 25.4%, no symptoms in 12.6%, shortness of breath with cough in 1.5%, dystria in 0.4%, and sputum in 0.5% of patients. There was. 3963 patients, 96.8% had a CT scan and 133 patients, 3.2% did not have a chest CT scan. Examination of troponin level showed that 3945 patients had negative CTNI 96.8% and only 153 patients had positive CTNI 3.7%. The most common inpatient departments were surgical department 30.6%, transplant department 28.43% and infectious department 18.4% respectively, of which 24.2% of 1018 patients needed ventilators. In examining the outcome of the patients, it showed that 23.7% of the patients died. The average hospitalization period of the patients was 6.7 ± 4.4 days. The minimum hospitalization period was 1 day and the maximum hospitalization period was 55 days. Based on chi-square test, there was a significant relationship between serum troponin level and the need for mechanical ventilation (P<0.001). There was a significant relationship between serum troponin level and the outcome of patients with covid (P<0.001). There was a significant relationship between gender and pulmonary involvement in patients with covid (P<0.05). The mean age of patients with covid-19 with pulmonary involvement (60.4 ± 16.6 years) was higher than that of non-pulmonary patients (54.6 ± 17.8 years) (P<0.05). Therefore, pulmonary involvement was more observed in older patients. Based on statistical tests, the age of patients with positive CTNI (69.9 ± 11.8 years) was higher than that of negative CTNI patients (59.9± 16.8 years) (P<0.05).