The Relationship between serum Copper Status and iron indices in Non-Alcoholic Fatty Liver disease patients

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease in many parts of the world. In previous investigations in NAFLD patients, low serum copper levels and high ferritin levels have been reported, and the theory of the relationship between copper status and metabolism has not yet been proven; The aim of this study is to investigate the relationship between the status of serum copper level and iron metabolism in patients with NAFLD. Materials and methods: In this cross-sectional study, patients who referred to the Sheikh Al-Rais Clinic who had fatty liver according to the ultrasound report and who met the inclusion criteria and agreed to participate in the study were randomly selected and serum levels of copper and iron biomarkers including ferritin, iron, total iron binding capacity were measured ; The test results of the patients were recorded using a pre-prepared form, and the information was entered into the SPSS software after categorization, and analysis and appropriate statistical tests were performed on them, and in all statistical tests, the level of statistical significance was 0.05 in considered Results: In the current study, 122 patients with NAFLD were included, whose average age was 39.54 ± 12.63 years, and 40.2% of them were men; The average body mass index in this population was 31.95 ± 6.87 kg/m2 and the examination of the results of requested tests revealed that the average copper serum level in these patients was 113.60 ± 34.56 micrograms per deciliter, the average level Serum iron in the participants of this study was 84.79 ± 38.36 μg/dL, the mean serum ferritin in these patients was 118.13 ± 161.10 ng/ml and the mean serum AST level was 27.32 ± 16.85 mg/dL. deciliter and ALT was 35.16 ± 27.74 mg/dL. 16.4% of patients had a copper level higher than 140 and only 0.8% of patients had a copper level less than 70. There was no significant relationship between serum copper level and serum ALT and AST and serum iron (P=0.650, r=0.044, P=0.798, r=0.025 and P=0.069 respectively) and r=0.165)