Comparison of fat injection with and without Platelet-rich plasma in the treatment of nasolabial folds and cheeks

Abstract

Skin aging is characterized by a decrease in skin thickness and extracellular matrix content, which leads to a weakening of the mechanical and viscoelastic strength of the skin. The development of skin wrinkles starts around the age of 30 and shows itself more in the 40s and later in the 50s. Currently, the effects of PRP in dermatology and skin rejuvenation are increasing during the studies of his researchers in this field. The aim of the present study was to compare fat injection with fat injection with PRP in the treatment of nasolabial folds and cheek folds. Materials and Methods: In this single-blind randomized clinical trial study, 30 patients who referred for nasolabial fold correction were studied in two groups: fat injection with PRP (intervention) and fat injection without PRP (control). The fat was centrifuged for 10 minutes at 1000 rpm, and to prepare PRP the blood was first centrifuged at 1500 rpm for 7 minutes and then for 5 minutes at 3400 rpm. The degree of improvement in the appearance of facial wrinkles was assessed by a single PRP injection using the Wrinkle Severity Scale (WSRS). The results of the two study groups were compared. The results of the two groups regarding the severity of facial wrinkles, the degree of tissue healing and homogeneity of the skin, as well as the degree of patient self-satisfaction at follow-up at the beginning of treatment and between the two groups were compared. Results: The mean age of the patients was 45.33±8.40 years ranging from 28 to 58 years and all patients were female. None of the patients had a history of the disease. Significantly, the rate of improvement of cheek and nasolabial folds was better in the patients of the intervention group (p=0.014 and p=0.005, respectively). Evaluation of post-treatment complications showed that only one case of post-injection complication was observed in the control group for the first time, which was related to dermatitis and a case of injection site reaction, erythema, bruising, papules, nodules, irritation, dermatitis and pruritus in the group. No intervention was observed. In the intervention group, the stability of treatment in all patients at the final visit was significantly higher than the control group and all patients in the intervention group had high stability (p=0.024). Satisfaction in the intervention group was high in 73.3% of patients and very high in 26.7%.