Study of the effect of continuous use of Tadalafil on men’s sexual function after posterior urethroplasty surgery – clinical trial

Abstract

Posterior urethral injuries in men commonly occur following pelvic and perineal trauma. These injuries may result from road accidents, occupational injuries, or natural disasters such as earthquakes and similar cases involving young and middle-aged people. One of the known complications in these patients is impotence, Whether due to the severity of the initial trauma or possibly in severe cases and the complex resulting from the surgery itself. This study aimed to evaluate the effect of continuous use of tadalafil after posterior urethroplasty on male sexual function. Materials and Methods: In this study, individuals who are candidates for posterior urethroplasty due to traumatic urethral injury were divided into two groups of intervention and placebo. One group received continuous treatment with tadalafil (10 mg daily), and the other group received a placebo. Other services were provided equally to both groups. Both groups were assessed with the International Erectile Dysfunction Index (IIEF) questionnaire before and after the intervention, and the results were evaluated. Results: 40 patients were studied in two groups of 20 with a mean age of 43.87±15.70 years. The most common cause of duct injury in the patients studied was pelvic fracture. Before the intervention, the mean score of IIEF patients was 14.85±7.39 in the intervention group and 14.77±6.48 in the placebo group. There was no statistically significant difference between the two groups (p=0.962), and the patients of the two groups were similar in terms of the severity of erectile dysfunction at the beginning of the study. In the follow-up of the third month after the intervention, in terms of IIEF score, the mean score in the intervention group was 20.12±4.94 and in the placebo group was 18.05±4.88. There was no statistically significant difference between the two groups (p=0.063). The score was significantly increased by 5.27±4.04 units (p<0.001). In the placebo group, the IIEF score was significantly increased by 3.27±2.97 (p<0.001). Significantly, the rate of IIEF increase in the intervention group was higher than in the placebo group during the follow-up time (p=0.022).