Evaluation of single dose of Pregabalin and Gabapentin on pain management after upper limb orthopedic surgery in patients with a history of coronary artery bypass graft surgery

Abstract

Postoperative pain control is a major concern for physicians and patients undergoing surgery. Inadequate pain control after surgery increases the risk of chronic pain. In addition, it can cause acute sleep disturbances, decreased respiratory movements, as well as cough suppression and sputum secretion. Chronic pain can also cause ischemic myocardial infarction, pulmonary infection, ileus, urinary retention, thromboembolism, increased immune function impairment, cost of anxiety, and long-term anxiety. To be. Pain control is especially important in orthopedic patients because poor pain control in them can be accompanied by delayed movement and limited joint movements. Therefore, we decided to manage the pain after upper orthopedic surgery in patients with a history of coronary artery bypass grafting in patients admitted to the orthopedic ward of Imam Reza (AS) hospitals in Tabriz, using a single dose of pregabalin and gabapentin. Materials and Methods: This study was a double-blind clinical trial that compares the effect of gabapentin and pregabalin in patients undergoing upper limb orthopedic surgery. After surgery, patients were divided on the basis of a random number table and based on the number of patients admitted to the study. During the first 24 hours after follow-up surgery, assessment of postoperative pain was initially performed in recovery at zero hours, then at 12 and 24 hours by an uninformed researcher, and was performed by AS. Opioid requirement was also recorded in different conditions. Finally, the data were compared with t-test and Chi-square. Results: There was no significant difference in pain intensity between the two groups in any of the mentioned times; However, it should be noted that pain intensity at all times in the pregabalin group was significantly less than the gabapentin group (P <0.05). There was no significant difference between the two groups in the average amount of pethidine consumed and in the number of people who needed pethidine (P <0.05); Of course, it should be noted that both in the number of people who needed pethidine injection and in the amount of pethidine consumed, the group receiving pregabalin was non-significantly lower.